Teneligliptin 20 mg + Metformin 500 (SR) mg is an oral medicine belonging to the category of antidiabetic drugs and is used for the management of type 2 Diabetes mellitus.

More Common  

1. Headache 
2. Cough 
3. Constipation 
4. Excessive sweating 
5. Weakness 
6. Unusual muscle pain 
7. Feeling cold 
8. Trouble breathing 
9. Feeling dizzy, light-headed, tired, or very weak 
10. Stomach pain, vomiting 
11. Slow or irregular heart rate. 

Less Common 

1. Swelling of the face, lips, or eyelids 
2. Heartburn 
3. Liver enzyme elevation 
4. Low blood sugar 
5. Nausea, upset stomach 
6. Diarrhea 

In type 2 diabetes, the body either doesn’t produce enough insulin or doesn’t respond to it properly, leading to high blood sugar levels. Metformin works mainly in the liver: it reduces how much glucose the liver produces and helps muscles use insulin more effectively. Teneligliptin belongs to a group called DPP-4 inhibitors. It stops the breakdown of hormones like GLP-1 and GIP, which signal the pancreas to release insulin after meals and reduce glucagon, the hormone that raises blood sugar.

Pregnancy

Due to a lack of studies on the effects of Teneligliptin and metformin on the fetus during pregnancy, its safety is not clearly established. Therefore, if you are pregnant or planning to conceive, inform your doctor.

Breastfeeding

Small amounts of Teneligliptin and metformin pass into breast milk. Tell your doctor if you are breastfeeding or plan to breastfeed, and they will advise you whether to stop breastfeeding or stop the medicine.

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the drug is made into a less toxic form in the liver and kidney, so consult a doctor before using them.

Alcohol and smoking can simultaneously affect the drug’s action and show an effect on blood glucose levels by affecting the liver and pancreas. It can sometimes increase blood sugar levels and sometimes decrease blood sugar levels.

Avoid taking Teneligliptin and Metformin with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Teneligliptin- {(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl] -2-pyrrolidinyl} (1,3-thiazolidin-3-yl) methanone

Metformin-N, N-dimethylimidodicarbonimidic diamide

Daily dose

Take Teneligliptin and metformin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 400 mg of Teneligliptin and 2550 mg of metformin per day, as it may cause severe overdosing effects like extreme dizziness, confusion, low blood pressure, liver damage, low blood sugar levels, swelling, muscle damage, and seizures. If overdosing effects remain unchanged, supply the patient with fruit or glucose liquids and sugary foods to minimize the effects, and meet the doctor.

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

1. Take Teneligliptin and metformin exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Teneligliptin and metformin without your doctor’s approval, even if you feel better. 
3. If you forget to take Teneligliptin and metformin, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

The Teneligliptin + metformin combination is a medicine used to manage type 2 diabetes when diet and exercise alone aren’t enough. It works in two ways: Teneligliptin helps the body release more insulin and reduce excess sugar made by the liver, while metformin lowers sugar production and improves how the body uses insulin. Together, they help control blood sugar levels without causing too many lows. Common side effects include stomach upset, headache, dizziness, and tiredness, which are usually mild and manageable. It’s not suitable for people with serious kidney, liver, or heart problems, or during pregnancy. Alcohol should be avoided while taking it, as it can increase the risk of serious complications like lactic acidosis. To reduce stomach issues, it’s best taken with meals.

What is the typical dose when teneligliptin is combined with metformin?

Teneligliptin and metformin are one of the most effective combinations for the treatment of type 2 diabetes, and the commonly used dose of teneligliptin is 20 mg in different combinations of metformin.

What do teneligliptin and metformin tablets treat?

Teneligliptin and metformin are a combination medicine used to manage type 2 diabetes when diet and exercise alone aren’t enough. It works in two ways: teneligliptin helps the body release more insulin and reduce excess sugar made by the liver, while metformin lowers sugar production and improves how the body uses insulin 

What is the mode of action of Teneligliptin and Metformin?

Metformin lowers liver glucose production and improves insulin sensitivity, while teneligliptin boosts incretin hormones to enhance insulin release and reduce glucagon. Together, they improve post‑meal blood sugar control with less risk of hypoglycemia.

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