Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg tablet is used to control blood sugar in people with type 2 diabetes. Glimepiride helps the pancreas release more insulin, Metformin (SR) reduces sugar made by the liver and improves how the body responds to insulin, and Pioglitazone makes the body use insulin more effectively. Together, they keep blood sugar under control and lower the risk of diabetes complications. Common side effects include low blood sugar, nausea, stomach upset, diarrhea, bloating, weight gain, swelling, headache, and dizziness. It should always be taken with food, meals should not be skipped, and alcohol should be avoided. Taking more than 1000 mg of combination per day can be dangerous and may cause nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.

Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15mg is used to treat Type 2 diabetes mellitus. This medicine belongs to antidiabetics category.

More Common  

1. Low blood sugar (hypoglycemia) 
2. Nausea 
3. Stomach pain 
4. Diarrhea 
5. Vomiting 
6. Headache 
7. Dizziness 
8. Weakness 

Less Common 

1. Skin rash 
2. Itching 
3. Loss of appetite 
4. Metallic taste in mouth 
5. Breathing difficulty 
6. Lactic acidosis 

Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg tablet works by lowering blood sugar levels in different ways. Glimepiride increases insulin release from the pancreas, while Metformin reduces glucose production in the liver and improves insulin sensitivity. Together, they help control blood sugar effectively in people with type 2 diabetes.

Pregnancy

Pregnant women should take Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15mg, take only if advised by a doctor, because blood sugar control during pregnancy needs careful monitoring

Breastfeeding

 Breastfeeding mothers should consult a doctor before taking Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15mg, as it may pass into breast milk.

Kidney and Liver Problems

People with kidney disease should use Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15mg carefully and only under medical advice, as Metformin may accumulate and increase the risk of lactic acidosis.

Low Blood Sugar

Do not skip meals while taking Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg, as it may cause hypoglycemia leading to sweating, dizziness, confusion, or fainting.

Take Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg, with food to reduce stomach upset and prevent low blood sugar. Avoid alcohol, as it may increase the risk of hypoglycemia and lactic acidosis. Maintain a healthy diabetic diet and regular exercise for better blood sugar control.

Avoid taking Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg combination with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Metformin- N, N-dimethylimidodicarbonimidic diamide

Glimepiride—3‑Ethyl‑4‑methyl‑N‑[2‑(4‑{[(trans‑4‑methylcyclohexyl) carbamoyl] sulfamoyl} phenyl)ethyl]‑2‑oxo‑2,5‑dihydro‑1H‑pyrrole‑1‑carboxamide

Pioglitazone- 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

Daily dose

Take Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor

Missed Dose

 If you forget to take Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15mg, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than the prescribed dose. Taking too much may cause nausea, vomiting, diarrhea, stomach pain, or severe abdominal discomfort. In rare cases, allergic reactions may occur. Seek immediate medical attention if any severe symptoms develop.

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

1. Take Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

What is the mode of action of Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg?

Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15mg works by lowering blood sugar levels in two ways. Glimepiride increases the release of insulin from the pancreas, while Metformin reduces glucose production in the liver and improves the body’s response to insulin. Together, they help control blood sugar in people with type 2 diabetes.

What are the uses of Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg?

Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg tablets are used to treat type 2 diabetes mellitus. They help control high blood sugar levels, improve insulin action, and reduce the risk of diabetes-related complications when combined with proper diet and exercise.

What are the side effects of Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg tablets?

Common side effects of Metformin 500 mg (SR) + Glimepiride 2 mg + Pioglitazone 15 mg tablets include low blood sugar, nausea, stomach pain, diarrhea, vomiting, headache, dizziness, and weakness. Some people may also experience loss of appetite or a metallic taste in the mouth.

1. PubChem. Metformin hydrochloride [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
2. Glimepiride [Internet]. Drugs.com. c2026 [cited 2026 Jul 18]. Available from. 
3. Pioglitazone [Internet]. Drugs.com. c2026 [cited 2026 Jul 18]. Available from. 
4. National Center for Biotechnology Information (2026). PubChem Compound Summary for CID 4829, Pioglitazone. Retrieved July 18, 2026 Available from.