This medicine contains Paracetamol 125 mg, Phenylephrine Hydrochloride 5 mg, and Cetirizine Dihydrochloride 2 mg per 5 ml of syrup. Each of these ingredients works together to provide effective relief from symptoms of common cold, flu, and allergies. 

Paracetamol helps reduce fever and relieves pain such as headache and body ache. Phenylephrine works as a nasal decongestant by reducing swelling in the blood vessels of the nose, which helps clear a blocked nose and makes breathing easier. Cetirizine is an antihistamine that blocks the action of histamine, a chemical responsible for allergy symptoms like sneezing, runny nose, watery eyes, and itching. 

Together, these three ingredients provide comprehensive relief from cold, flu, and allergy-related discomfort. 

Paracetamol 125 mg, Phenylephrine hydrocloride 5mg, Cetirizine Dihydrocloride 2mg / 5 ml is used to relieve and treat conditions such as:

1. Common cold 
2. Allergic rhinitis (sneezing, runny or itchy nose) 
3. Fever associated with cold and flu 
4. Headache and body ache 
5. Nasal congestion 
6. Watery eyes caused by allergies     

More Common

1. Drowsiness or sleepiness 
2. Dry mouth or throat 
3. Mild headache 
4. Nausea or stomach discomfort 
5. Restlessness or trouble sleeping      

Less Common 

1. Increased heart rate or palpitations 
2. High blood pressure 
3. Allergic reaction (rash, itching, or swelling) 
4. Dizziness 
5. Liver problems      

This medicine contains paracetamol, phenylephrine hydrochloride, and cetirizine dihydrochloride. Paracetamol reduces fever and pain by blocking the production of chemicals responsible for pain and high body temperature. Phenylephrine hydrochloride works as a decongestant by narrowing the blood vessels in the nasal passages, reducing swelling and helping clear a blocked nose. Cetirizine dihydrochloride is an antihistamine that blocks histamine, a chemical responsible for allergy symptoms such as sneezing, itching, watery eyes, and runny nose. Together, these ingredients provide relief from cold, flu, and allergy symptoms.

Allergy or Hypersensitivity

Do not use this medicine if you are allergic to paracetamol, phenylephrine, cetirizine, or any other ingredients. Inform your doctor if you have experienced allergic reactions previously.

High Blood Pressure or Heart Problems

Consult your doctor before using this medicine if you have high blood pressure, heart disease, or irregular heartbeat, as phenylephrine may increase blood pressure.

Liver Disease

Inform your doctor if you have liver disease, as paracetamol may require dose adjustment and monitoring.

Glaucoma

Consult your doctor before using it if you have glaucoma, as phenylephrine may increase pressure inside the eyes.

Thyroid Problems

Inform your doctor if you have hyperthyroidism, as phenylephrine may increase heart rate and cause palpitations.

Avoid alcohol while taking this medicine as it may increase drowsiness. Avoid excessive caffeine intake as it may increase restlessness or fast heartbeat. Drink plenty of fluids to stay hydrated. 

Avoid taking Paracetamol 125 mg, Phenylephrine hydrocloride 5mg, Cetirizine Dihydrocloride 2mg / 5 ml with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Cetirizine: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid  

Phenylephrine: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol

Paracetamol: N-(4-hydroxyphenyl) acetamide

Daily dose

Take Paracetamol 125 mg, Phenylephrine hydrocloride 5mg, Cetirizine Dihydrocloride 2mg / 5 ml exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

 If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take Cetirizine more than 10 mg, Phenylephrine more than 10 mg, and Paracetamol 4000 mg (4 g) per day, as overdose may cause drowsiness, dry mouth, nausea, vomiting, stomach pain, restlessness, high blood pressure, liver damage, or severe allergic reactions; seek medical help immediately if this happens.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.    

Can Cetirizine and Paracetamol be taken together? 

Yes, they can be taken together. Cetirizine helps with allergies, and Paracetamol reduces fever and pain. But please don’t take more than the recommended dose. 

What are the side effects of Cetirizine? 

Common side effects include sleepiness, dry mouth, dizziness, and headache. Rarely, it may cause stomach upset or allergic skin reactions. These effects are usually mild and go away on their own. 

Is Cetirizine safe during pregnancy? 

Cetirizine is generally considered safe in pregnancy when used at the recommended dose. However, it should be taken only if advised by a doctor, especially during the first trimester, to ensure safety for both mother and fetus. 

What are the side effects of Paracetamol? 

Paracetamol is usually safe when taken in the correct dose. Rare side effects may include nausea, stomach pain, rash, or allergic reaction. Taking too much can cause serious liver damage, so always follow the recommended dose.  

What are the uses of Paracetamol? 

Paracetamol is used to reduce fever and relieve mild to moderate pain such as headache, toothache, body pain, muscle pain, back pain, and pain due to cold or flu. 

What are the uses of Phenylephrine? 

Phenylephrine is used to relieve nasal congestion caused by common cold, allergies, or sinusitis. It helps clear blocked nose and makes breathing easier. 

What is the class of Phenylephrine? 

Phenylephrine belongs to the nasal decongestant and sympathomimetic class of drugs. It works by narrowing blood vessels in the nose to reduce swelling and congestion. 

Reference  

1. PubChem. Cetirizine [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
2. PubChem. Phenylephrine [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
3. PubChem. Acetaminophen [Internet]. Pubchem. PubChem; 2020. Available from 
4. Thornton P. Cetirizine Hcl: Uses, Dosage & Side Effects [Internet]. Drugs.com. 2021. Available from 
5. Richards E, Maani CV. Phenylephrine [Internet]. Nih.gov. StatPearls Publishing; 2023. Available from 
6. Durbin K. Acetaminophen [Internet]. Drugs.com. Drugs.com; 2023. Available from