Diclofenac 50 mg + Paracetamol 325 mg contains diclofenac and paracetamol and is used to relieve pain, swelling, inflammation, and fever in conditions such as joint pain, muscle pain, back pain, toothache, ear pain, throat pain, injury pain, and arthritis. Diclofenac 50 mg + Paracetamol 325 mg works by reducing pain and inflammation, giving better overall relief. It is best taken with food or after food to reduce stomach irritation, and alcohol should be avoided because it may increase the risk of stomach problems, bleeding, and liver damage. People with allergy to painkillers, stomach ulcer, liver or kidney disease, heart disease, high blood pressure, asthma triggered by painkillers, or bleeding problems should not take this medicine without a doctor’s advice.  

Diclofenac 50 mg + Paracetamol 325 mg is  used to treat in the following conditions:

1. Gallstones (cholesterol stones) 
2. Primary Biliary Cholangitis (liver disease) 
3. Protects liver cells in liver disorders  

1. Take Diclofenac 50 mg + Paracetamol 325 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Diclofenac 50 mg + Paracetamol 325 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Diclofenac 50 mg + Paracetamol 325 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

More Common  

1. Black stools or blood in stools 
2. Vomiting blood 
3. Severe stomach pain 
4. Yellow eyes or yellow skin (possible liver problem) 
5. Breathing difficulty / chest tightness 
6. Swelling of face, lips, or throat 
7. Severe skin rash / allergy 

Less Common 

1. Black stools or blood in stools (possible stomach bleeding) 
2. Vomiting blood 
3. Severe stomach pain 
4. Yellow eyes or yellow skin  
5. Swelling of face, lips, or throat 
6. Breathing difficulty  

Diclofenac 50 mg + Paracetamol 325 mg works by reducing pain, swelling, inflammation, and fever. Diclofenac blocks the production of prostaglandins, which are chemicals that cause pain and inflammation. Paracetamol helps reduce pain and fever by acting on the brain’s pain and temperature control center. Together, they give better relief from pain and swelling. 

Allergic Reactions

 People allergic to Diclofenac 50 mg + Paracetamol 325 mg, or any ingredients of this medication are not recommended to take this medicine as it can cause serious allergic reactions like rash, swelling, or trouble breathing. Always ask your doctor first. 

Liver Disease Monitoring

If you have liver disease, consult your doctor before taking Diclofenac 50 mg + Paracetamol 325 mg because it can increase the risk of liver damage. 

Kidney problems

If you have kidney disease, consult your doctor before taking Diclofenac 50 mg + Paracetamol 325 mg because it can worsen kidney function. 

Heart problems

If you have heart disease or high blood pressure, consult your doctor before taking this medicine because it can cause fluid retention and may worsen heart problems. 

Asthma

If you have asthma, especially after taking painkillers, consult your doctor before taking this medicine because it can trigger breathing problems.

Pregnancy

If you are pregnant, consult your doctor before taking this medicine because it may affect the baby, especially in the later months of pregnancy.

Breastfeeding

If you are breastfeeding, consult your doctor before taking this medicine because small amounts may pass into breast milk and may affect the baby.

This medicine can be taken after food to help reduce stomach upset. It is best to avoid or limit alcohol while taking this medicine because it can increase drowsiness and may raise the risk of stomach irritation or liver problems. Very heavy or oily meals may also cause more stomach discomfort in some people. 

Avoid taking Diclofenac 50 mg + Paracetamol 325 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry) Name

Diclofenac: 2-[2-(2,6-dichloroanilino)phenyl]acetic acid 

Paracetamol: N-acetyl-para-aminophenol (APAP), acetaminophen

Daily dose

Take Diclofenac 50 mg + Paracetamol 325 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

 It is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Can paracetamol make you sleepy? 

Yes, paracetamol is made up of acetaminophen, which is responsible for causing drowsiness, a common side effect. 

Can paracetamol cure colds? 

No, paracetamol is used to treat pain and fever. 

How many paracetamols can we take in a day? 

An adult can take up to 2 tablets of 500 mg with a 6-hour gap, up to four times a day. Children aged 10-15 years can take 1 tablet four times a day, with a gap of 4-6 hours between doses. 

What are the uses of Diclofenac? 

Diclofenac is used to relieve pain, inflammation, and swelling in conditions such as arthritis, muscle and joint pain, back pain, injury-related pain, and menstrual pain. 

What is the mechanism of action of Diclofenac? 

Diclofenac works by blocking cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins responsible for pain, inflammation, and swelling. 

What is the drug class of Diclofenac? 

Diclofenac belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs), which help reduce pain, inflammation, and swelling. 

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