Itraconazole 130 mg is an antifungal medication. It kills and stops the growth of fungi by destroying its cell membrane, that is by working on inhibiting the synthesis of ergosterol, which is a crucial compound in the fungal cell membrane, thereby treating your skin infection. Side effects of this medication usually include decreased urine output, dry mouth, fever, increased thirst, irregular heartbeat, loss of appetite, mood changes, and muscle pain or cramps. Alcohol, smoking and grapefruits should be avoided with itraconazole, taking more than 400 mg of itraconazole per day, as it may cause severe overdosing effects like extreme nausea and vomiting, abdominal pain. 

Itraconazole 130 mg is used to treat fungal infection such as:

1. Lung infection caused by fungus (aspergillosis) 
2. Serious body infections caused by fungus (blastomycosis or histoplasmosis) 
3. Fungal infection in the food pipe (esophageal candidiasis) 
4. Fungal infection of the fingernails 
5. Fungal infection of the toenails         

More Common  

1. Decreased urine output 
2. Dry mouth 
3. Fever 
4. Increased thirst 
5. Irregular heartbeat 
6. Loss of appetite 
7. Mood changes 
8. Muscle pain or cramps 
9. Nausea 
10. Numbness or tingling in the hands, feet, or lips 
11. Seizures 
12. Trouble breathing 
13. Unusual tiredness or weakness 
14. Vomiting           

Less Common 

1. Blurred vision 
2. Chest pain or tightness 
3. Chills 
4. Clay-colored stools 
5. Cloudy urine 
6. Cold sweats 
7. Confusion 
8. Cough 
9. Dark urine 
10. Decrease in urine-concentrating ability 
11. Diarrhea 
12. Dizziness 
13. Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position 
14. Drowsiness 
15. Feeling unusually cold 
16. Headache 
17. Itching, skin rash 
18. Light-colored stools 
19. Mental changes        

Itraconazole 130 mg works by blocking an enzyme that the fungus needs to make its cell membrane. The cell membrane is an important protective layer of the fungus. When this membrane is not formed properly, the fungus becomes damaged, cannot survive normally, and eventually dies. This helps treat the fungal infection.

Allergy or Hypersensitivity

Tell your doctor if you had experienced an allergic reaction to itraconazole. If you had symptoms like rash, itching, swelling, or breathing trouble, this medicine should be avoided. 

Pregnancy

Itraconazole should not be used during pregnancy unless clearly advised by a doctor, because it may harm the baby’s growth and development. It is usually used only when no safer option is available. 

Kidney Disease

 If you have a history of kidney problems, tell your doctor before taking itraconazole. This medicine may worsen kidney function in some people and may need careful monitoring. 

Liver Disease

If you have liver disease or a history of liver problems, tell your doctor before taking this medicine. Itraconazole can affect the liver and may make liver problems worse. 

Congestive Heart Failure

If you have heart failure or a history of heart failure, itraconazole should be used very carefully or avoided, especially for nail fungal infections, because it may worsen heart function. 

Organ Transplant / Acid-Reducing Medicines

If you have had an organ transplant, tell your doctor before using itraconazole. Many transplant patients take medicines that reduce stomach acid, and this can make itraconazole absorb poorly, so the medicine may not work properly. 

Itraconazole 130 mg has an interaction with grapefruit Juice, so it is better to avoid it. Alcohol and smoking can simultaneously affect the drug’s action, so they may cause severe drowsiness and sedation. 

Avoid taking Itraconazole 130 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Itraconazole: (2R,4S)-rel-1-[2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy-4-[4-(4-[pentyloxy]phenyl)piperazin-1-yl]phenyl]butan-2-ol 

Daily dose

Take Itraconazole 130 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Don’t take more than 400 mg of itraconazole per day, as it may cause severe overdosing effects like extreme nausea, vomiting, abdominal pain, headache, dizziness or lightheadedness, fatigue or weakness, and skin rash. Consult a doctor if you experience any of these symptoms.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children. 

1. Take Itraconazole 130 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Itraconazole 130 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Itraconazole 130 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

What are the uses of Itraconazole 130 mg? 

Itraconazole 130 mg tablets are used to treat fungal infections in the body. They are commonly used for nail fungal infections (fungal infection of fingernails or toenails) and used for certain serious fungal infections in the lungs or other parts of the body, depending on the form prescribed by the doctor. 

What are the side effects of Itraconazole 130 mg? 

Itraconazole 130 mg side effects generally include decreased urine output, dry mouth, fever, increased thirst, irregular heartbeat, loss of appetite, mood changes, muscle pain or cramps, nausea, numbness or tingling in the hands, feet, or lips, seizures.

Can Itraconazole 130 mg be used during pregnancy? 

Itraconazole 130 mg should generally be avoided during pregnancy unless the doctor feels it is absolutely necessary. It may harm the unborn baby, so it is usually used only when the benefit is greater than the risk, especially in serious infections. 

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