Itraconazole 100 mg tablet is an antifungal medication. Itraconazole 100 mg kills and stops the growth of fungi by destroying its cell membrane, that is by working on inhibiting the synthesis of ergosterol, which is a crucial compound in the fungal cell membrane, thereby treating your skin infection. Side effects of Itraconazole 100 mg usually include decreased urine output, dry mouth, fever, increased thirst, irregular heartbeat, loss of appetite, mood changes, and muscle pain or cramps. Alcohol, smoking and grapefruits should be avoided with itraconazole, taking more than 400 mg of itraconazole per day, as it may cause severe overdosing effects like extreme nausea and vomiting, abdominal pain.  

Itraconazole 100 mg is an oral antifungal medicine belonging to the triazole class of drugs.Itraconazole 100 mg is used to treat fungal infections in various parts of the body including:

1. Food pipe (esophageal candidiasis) 
2. Lung
3. Fingernails 
4. Toenails 

More Common

1. Decreased urine output 
2. Dry mouth 
3. Fever 
4. Increased thirst 
5. Irregular heartbeat 
6. Loss of appetite 
7. Mood changes 
8. Muscle pain or cramps 
9. Nausea 
10. Numbness or tingling in the hands, feet, or lips 
11. Seizures 
12. Trouble breathing 
13. Unusual tiredness or weakness 
14. Vomiting 

Less Common

1. Blurred vision 
2. Chest pain or tightness 
3. Chills 
4. Clay-colored stools 
5. Cloudy urine 
6. Cold sweats 
7. Confusion 
8. Cough 
9. Dark urine 
10. Decrease in urine-concentrating ability 
11. Diarrhea 
12. Dizziness 
13. Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position 
14. Drowsiness 
15. Feeling unusually cold 
16. Headache 
17. Itching, skin rash 
18. Light-colored stools 
19. Mental changes 

Itraconazole 100 mg works by blocking a fungal enzyme called cytochrome P450 14α-demethylase, which is responsible for making ergosterol, an essential part of the fungal cell membrane. By stopping the formation of ergosterol, it damages the cell membrane, which leads to the death of the fungus and helps treat the infection.

1. If you forget to take Itraconazole 100 mg, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.  
2. Itraconazole 100 mg should be taken after meals or as advised by your doctor.  
3. Follow your doctor’s instructions on the dosage and timing of Itraconazole 100 mg.  
4. Swallow Itraconazole 100 mg with a glass of water. Do not crush, break, or chew it. 

Allergies or Hypersensitivity

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. 

Pregnancy

Itraconazole 100 mg can harm a baby’s growth if taken during pregnancy, especially affecting the brain and causing tremors, developmental issues, and respiratory depression. Doctors only use it if no safer medicine works

Kidney Disease and Liver Disease

If you have any history of kidney or liver disease tell your doctor as Itraconazole 100 mg may worsen your kidney and liver’s condition.

Congestive Heart Failure

If you have a history of heart failure, Itraconazole 100 mg should not be used to treat fungal infections of the fingernails or toenails, as it may worsen your heart condition.

Organ Transplant

After organ transplant, you might take medicines which will suppress the release of stomach’s acid by which your stomach might not absorb itraconazole properly. Hence it is advised to avoid itraconazole in such cases.

Itraconazole 100 mg has an interaction with grapefruit Juice, so it is better to avoid it. Alcohol and smoking can simultaneously affect the drug’s action, so they may cause severe drowsiness and sedation. 

Avoid taking itraconazole 100 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

(2R,4S)-rel-1-[2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy-4-[4-(4-[pentyloxy]phenyl)piperazin-1-yl]phenyl]butan-2-ol 

Daily Dose

Take Itraconazole 100 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Don’t take more than 400 mg of itraconazole per day, as it may cause severe overdosing effects like extreme nausea, vomiting, abdominal pain, headache, dizziness or lightheadedness, fatigue or weakness, and skin rash. Consult a doctor if you experience any of these symptoms.

1. Store Itraconazole 100 mg at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Can I take itraconazole 100 mg twice daily? 

Itraconazole 100 mg is prescribed for onychomycosis (fungal nail infections), systemic fungal infections (like histoplasmosis, blastomycosis), oral or esophageal candidiasis (when severe or resistant to topical treatment) and aspergillosis (lung infection caused by fungus). Whereas it can be taken 2 times in the morning and evening.

What are Itraconazole 100 mg tablet use? 

Itraconazole 100 mg is used for the following infections like onychomycosis (fungal nail infections), systemic fungal infections (like histoplasmosis, blastomycosis), oral or esophageal candidiasis (when severe or resistant to topical treatment), aspergillosis (lung infection caused by fungus).

What are Itraconazole 100 mg tablet side effects? 

Itraconazole 100 mg side effects generally include decreased urine output, dry mouth, fever, increased thirst, irregular heartbeat, loss of appetite, mood changes, muscle pain or cramps, nausea, numbness or tingling in the hands, feet, or lips, seizures.

1. Itraconazole (oral route) [Internet]. Mayo Clinic. 2025 [cited 2025 Jul 14]. Available from 
2. https://www.facebook.com/Drugscom. Itraconazole Disease Interactions [Internet]. Drugs.com. 2025 [cited 2025 Jul 14]. Available from 
3. PubChem. Itraconazole [Internet]. Nih.gov. PubChem; 2025 [cited 2025 Jul 14]. Available from 
4. Kurn H, Wadhwa R. Itraconazole [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2021. Available from