Itraconazole 100 mg + Terbinafine 250 mg is a combination of two antifungal medicines used to treat a wide range of fungal infections. Itraconazole works for deeper or serious infections like lung infections, body-wide infections, and fungal infection in the food pipe, as well as nail infections. Terbinafine targets fungal infections of the skin, nails, and scalp, including ringworm, jock itch, athlete’s foot, and scalp infections. Together, they attack the fungus from different angles, helping clear infections more effectively.  

Common side effects include Itraconazole 100 mg + Terbinafine 250 mg stomach upset, headache, rash, and loss of appetite, while serious effects such as liver problems, severe rash, or allergic reactions require immediate medical attention. The combination should be used carefully in people with liver or kidney problems, and alcohol should be avoided. Pregnant or breastfeeding women should take it only if prescribed by a doctor. 

Itraconazole 100 mg + Terbinafine 250 mg is an oral antifungal medicine belonging to the category of allylamine antifungal medicine and is used to treat fungal infections in the following areas: 

1. Fingernails and toenails (onychomycosis) 
2. Groin area (jock itch)  
3. Feet (tinea pedis) 
4. Scalp (tinea capitis) 

1. Take Itraconazole 100 mg + Terbinafine 250 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Itraconazole 100 mg + Terbinafine 250 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Itraconazole 100 mg + Terbinafine 250 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

More Common  

1. Feeling sick or upset stomach 
2. Stomach pain or indigestion 
3. Loose stools (diarrhea) 
4. Headache 
5. Skin rash or itching 
6. Loss of appetite 
7. Changes in taste       

Less Common

1.  Dizziness or lightheadedness 
2. Muscle or joint pain 
3. Fatigue or weakness 
4. Yellowing of skin or eyes (sign of liver problem) 
5. Dark-colored urine 
6. Severe rash, blisters, or itching 
7. Trouble breathing, swelling of face/lips 

Itraconazole 100 mg + Terbinafine 250 mg are both antifungal medicines, but they work in slightly different ways to kill fungus. Itraconazole stops the fungus from making a key substance called ergosterol. Ergosterol is required by fungus to prepare its outer cover and shield itself from the surroundings. Terbinafine blocks ergosterol, causing fungus to die. Itraconazole works well for deep internal infections, whereas terbinafine for topical fungal infection 

Allergy Warning

Tell your doctor if you have ever had any unusual or allergic reaction to itraconazole, terbinafine, or any other antifungal medicine. Taking them again may cause serious allergies, rash, swelling, or breathing problems. 

Liver Problems

Do not take this combination if you have serious liver disease, because both medicines are processed by the liver and may worsen your condition. 

Kidney Problems

Their skin absorbs more medicine, which can increase the chances of side effects. Always consult your doctor before using it. 

Pregnant or Breastfeeding Women

Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The combination may not be safe for the fetus and should only be used if prescribed by a doctor. 

Itraconazole has an interaction with grapefruit Juice, so it is better to avoid it. While taking Terbinafine, avoid alcohol because it can put extra strain on your liver and increase the risk of liver damage. Try not to consume too much caffeine, such as tea, coffee, or energy drinks, since the medicine may slow down its breakdown and make you feel restless or unable to sleep.  

Avoid taking Itraconazole 100 mg + Terbinafine 250 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry) / Chemical name

Terbinafine: N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine 

Itraconazole: (2R,4S)-rel-1-[2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy-4-[4-(4-[pentyloxy]phenyl)piperazin-1-yl]phenyl]butan-2-ol 

Daily dose

Take Itraconazole 100 mg + Terbinafine 250 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

Don’t take more than 500 mg of terbinafine per day and 400 mg of itraconazole, as higher doses may cause overdosing effects like extreme nausea, vomiting, stomach pain, headache, dizziness, unusual tiredness, loss of appetite, dark urine, or yellowing of the skin/eyes. Consult a doctor immediately if you experience any of these symptoms. 

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

What are the uses of terbinafine? 

Terbinafine tablets are used to treat fungal infections such as nail fungus (fingernails and toenails), ringworm on the body, groin (jock itch), feet (athlete’s foot), scalp, and other skin infections caused by fungus. 

What are the side effects of terbinafine? 

Common side effects include stomach upset, diarrhea, headache, skin rash, loss of appetite, and changes in taste. Rarely, it may cause serious problems like yellowing of the skin or eyes, dark urine, severe rash, or trouble breathing if these happen, consult a doctor immediately. 

How does terbinafine work? 

Terbinafine works by blocking a substance the fungus needs to build its outer covering (cell wall). Without this, the fungus cannot grow and eventually dies, which helps clear the infection. 

Can I take terbinafine during pregnancy? 

Terbinafine is generally not recommended during pregnancy unless the doctor decides the benefits outweigh the risks. There is limited safety information in pregnant women, so it should only be used if necessary and prescribed by a doctor. 

Can I take itraconazole 100 mg twice daily? 

Itraconazole 100 mg is prescribed for onychomycosis (fungal nail infections), systemic fungal infections (like histoplasmosis, blastomycosis), oral or esophageal candidiasis (when severe or resistant to topical treatment) and aspergillosis (lung infection caused by fungus). Whereas it can be taken 2 times in the morning and evening.  

What are the uses of itraconazole? 

It is used for the following infections like onychomycosis (fungal nail infections), systemic fungal infections (like histoplasmosis, blastomycosis), oral or esophageal candidiasis (when severe or resistant to topical treatment), aspergillosis (lung infection caused by fungus) 

What are the side effects of itraconazole? 

Itraconazole side effects generally include decreased urine output, dry mouth, fever, increased thirst, irregular heartbeat, loss of appetite, mood changes, muscle pain or cramps, nausea, numbness or tingling in the hands, feet, or lips, seizures 

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