Clopidogrel 75 mg + Aspirin 150 mg tablet is an antiplatelet medicine. It is commonly prescribed in certain heart and blood vessel conditions, such as heart attack (acute coronary syndrome), or after certain coronary stent procedures. 

This medicine contains two active ingredients: clopidogrel and aspirin. Both medicines reduce the ability of platelets to stick together and form blood clots. By working together, they help reduce the risk of blood-vessel blockage and certain cardiovascular events. 

Common side effects include easy bruising, nosebleeds, stomach discomfort, indigestion, diarrhea, and headache. The most important risk is bleeding, which can occasionally be serious. 

Taking more than the recommended dose may increase the risk of excessive bleeding, stomach irritation, nausea, vomiting, dizziness, or other serious complications. Seek immediate medical attention if an overdose is suspected. 

Clopidogrel 75mg + Aspirin 150mg is used to treat the following conditions: 

1. Prevention of blood clots after certain coronary stent procedures 
2. Prevention of recurrent heart attack 
3. Prevention of other cardiovascular events in selected patients 
4. Other conditions requiring dual antiplatelet treatment, as determined by a doctor 
5. Heart attack (Acute coronary syndrome)       

More Common

1. Easy bruising 
2. Nosebleeds 
3. Stomach discomfort 
4. Indigestion 
5. Diarrhea 
6. Headache 
7. Prolonged bleeding from cuts        

Less Common 

1. Stomach ulcer 
2. Gastrointestinal bleeding 
3. Blood in the urine 
4. Vomiting blood 
5. Black or tar-like stools 
6. Severe or unexplained bruising 
7. Severe allergic reactions 
8. Skin rash 
9. Swelling of the face, lips, or throat 
10. Difficulty breathing 
11. Rarely, serious blood disorders        

This medicine contains blood clot preventing (antiplatelet) agents clopidogrel and aspirin that work by stopping platelets from sticking together and by preventing the signal that commands them to stick together. In this way, they make the blood less likely to form harmful clots and help reduce the risk of heart attack, stroke, and other blood vessel blockages. 

Allergy or Hypersensitivity

If you are allergic to clopidogrel, aspirin, or other antiplatelet medicines, avoid using this medicine. Serious allergic reactions such as rash, itching, swelling of the face or throat, or breathing difficulty may occur.

Bleeding Disorders

If you have a bleeding disorder or a history of unusual bleeding, taking clopidogrel and aspirin may make bleeding heavier or last longer. Inform your doctor before taking this medicine so they can decide whether it is safe for you.

Stomach Disorders

If you have stomach ulcers or a history of gastrointestinal bleeding, aspirin may irritate the stomach and increase the risk of bleeding. Tell your doctor about your stomach problems before taking this medicine.

Liver or kidney disease

If you have liver or kidney problems, tell your doctor before taking this medicine. Your doctor may need to monitor you more closely and decide whether this medicine is suitable for you.

Surgery or Dental Procedures

If you are going to have surgery or dental treatment, tell your doctor or dentist that you are taking this medicine. It can increase bleeding during or after the procedure. Do not stop the medicine on your own.

Other Blood-Thinning Medicines

If you are already taking blood thinners or other medicines that prevent blood clots, taking them together with clopidogrel and aspirin may further increase the risk of bleeding. Always tell your doctor about all the medicines you are taking.

This medicine can generally be taken before or after food. Avoid excessive alcohol consumption because alcohol may increase stomach irritation and the risk of bleeding. 

Avoid taking Clopidogrel 75mg + Aspirin 150mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Clopidogrel: methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c] pyridin-5-yl)acetate 

Aspirin: 2-acetyloxybenzoic acid 

Daily dose

Take Clopidogrel 75mg + Aspirin 150mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

 If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Taking more than the prescribed dose of Clopidogrel 75 mg + Aspirin 150 mg may increase the risk of excessive bleeding, stomach pain, nausea, vomiting, dizziness, or weakness. If you accidentally take too much of this medicine, contact your doctor or seek immediate medical attention.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.    

What are the uses of clopidogrel and aspirin tablets? 

Clopidogrel and aspirin are used to prevent harmful blood clots. They may be prescribed after a heart attack, in acute coronary syndrome, or after certain heart stent procedures.

What are the side effects of clopidogrel and aspirin tablets? 

Common side effects include easy bruising, nosebleeds, stomach discomfort, indigestion, diarrhea, and headache. The main serious risk is excessive bleeding.

Which is better, clopidogrel or aspirin? 

Clopidogrel or aspirin are both harmful if you are self-medicating it. This medication should be consumed only under doctor supervision. 

What foods should I avoid when taking clopidogrel? 

There are no major foods that must be avoided. Avoid excessive alcohol because it can increase the risk of bleeding and stomach irritation.

When is the best time to take aspirin and clopidogrel? 

Take them exactly as prescribed, preferably at the same time every day. They can generally be taken with or without food. If aspirin causes stomach discomfort, taking it with food may help. 

Reference  

1. PubChem. Clopidogrel [Internet]. Nih.gov. PubChem; 2019 [cited 2026 Aug 13]. Available from 
2. PubChem. Aspirin [Internet]. @pubchem. PubChem; 2019 [cited 2026 Aug 13]. Available from 
3. Squizzato A, Bellesini M, Takeda A, Middeldorp S, Donadini MP. Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events. Cochrane Database of Systematic Reviews [Internet]. 2017 Dec 14 [cited 2026 Aug 13];(12). Available from 
4. Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, et al. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. New England Journal of Medicine [Internet]. 2018 July 19 [cited 2026 Aug 13];379(3):215–25. Available from 
5. Albers GW, Amarenco P. Combination Therapy With Clopidogrel and Aspirin. Stroke. 2001 Dec;32(12):2948–9.