Cefixime 200 mg + Ofloxacin 200 mg is a combination antibiotic used to treat various bacterial infections such as respiratory tract infections, urinary tract infections, typhoid, and gastrointestinal infections. Cefixime works by preventing the formation of bacterial cell walls, while Ofloxacin blocks bacterial DNA replication, together leading to the death of bacteria. Common side effects include nausea, diarrhea, stomach pain, dizziness, and skin rash. This medicine should be avoided by individuals with kidney problems, epilepsy, bone related issues, or known allergies to antibiotics, unless prescribed by a doctor.  

Special precautions include avoiding dairy products, antacids, grapefruit or its juice, and alcohol during treatment. Patients should also limit sun exposure due to the risk of skin sensitivity. It is not recommended during pregnancy or breastfeeding unless clearly advised by a healthcare provider. The usual adult dose is one tablet (Cefixime 200 mg + Ofloxacin 200 mg) twice daily or as directed by the physician. 

Cefixime 200 mg + Ofloxacin 200 mg are oral medicines belonging to the class of antibiotics. They are used for the bacterial infections like: 

1. Respiratory tract infections (e.g., bronchitis, pneumonia) 
2. Urinary tract infections (UTIs) 
3. Typhoid fever 
4. Gastrointestinal infections (e.g., infectious diarrhea) 
5. Skin and soft tissue infections 
6. Sexually transmitted infections (like gonorrhea) 
7. Sinusitis (inflammation of the sinuses or nasal passages)  
8. Tonsillitis (infection or inflammation of the tonsils)  
9. Pharyngitis (an inflammation at the back of the throat) 

1. If you forget to take Cefixime +ofloxacin, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 
2. Take Cefixime +ofloxacin exactly as prescribed by your doctor, at the same time each day.  
3. Do not stop taking Cefixime +ofloxacin without your doctor’s approval, even if you feel better.

More Common  

1. Diarrhoea 
2. Nausea 
3. Dyspepsia (Indigestion) 
4. Loose stools 
5. Abdominal pain 
6. Vomiting 

Less Common

1. Joint or muscle pain 
2. Changes in taste or smell 
3. Discoloration of the tongue 
4. Increased risk of developing Clostridium difficile infection. 

This medicine works by stopping bacteria from building their protective wall, which causes them to die. Ofloxacin, a type of antibiotic, blocks the enzyme needed for bacteria to copy and repair their DNA, so the bacteria can’t grow or multiply. This combination offers enhanced coverage against both gram-positive and gram-negative bacteria and is commonly used to treat respiratory tract infections, urinary tract infections, gastrointestinal infections, and skin and soft tissue infections.  

Allergy/Hypersensitivity

If you have previously had an allergy to this medicine, inform your doctor. 

Pregnancy

This combination is generally not recommended during pregnancy, as it may harm the developing baby. Always consult your doctor if you are pregnant or planning to conceive. 

Alcohol abuse

Drinking alcohol while taking this medicine may increase dizziness or upset your stomach. It’s better to avoid alcohol during treatment. 

Liver disease

Impaired liver function may increase the risk of side effects and drug toxicity. Use this medicine cautiously if you have liver problems.  

Kidney Disease

If you have kidney disease, this medicine can stay in your body longer and cause harm. Tell your doctor if you have any kidney issues before you start.

Seizures or Epilepsy

Ofloxacin may increase the risk of seizures in people with epilepsy. If you have a history of fits or seizures, do not take this medicine without medical advice. 

Tendon Pain or Injury

Ofloxacin may cause swelling or tearing of tendons (like in your shoulder or heel). Stop using the medicine and inform your doctor if you feel pain or swelling in joints or muscles. 

Avoid taking Cefixime + Ofloxacin with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

 Avoid grapefruit or grapefruit juice while taking Cefixime + Ofloxacin, as it can reduce the medicine’s effectiveness. Calcium-rich foods like milk, cheese, curd and paneer reduce the absorption of ofloxacin in the stomach, so take the antibiotic at least 2 hours before or after such foods. Also, avoid alcohol, as it may increase side effects like dizziness and stomach upset. Smoking can weaken your immune response and delay recovery, so it’s best to avoid it during treatment. 

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Cefixime: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Ofloxacin: (RS)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid 

Daily dose

Take cefixime +ofloxacin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

Don’t take cefixime +ofloxacin more than 800 mg per day.  If you know someone who takes this medicine and have symptoms like dizziness, confusion and vomiting then rush them to hospital immediately 

1. What are the uses of Cefixime + Ofloxacin tablet? 

It is used to treat respiratory infections, urinary tract infections, typhoid, and stomach infections caused by bacteria. 

2. What are the side effects of Cefixime? 

Common side effects of cefixime include diarrhea, nausea, stomach pain, gas, and skin rash. 

3. What is the adult dosage for Cefixime 200 mg? 

The usual dose is 200 mg twice daily or 400 mg once daily, as prescribed by the doctor. 

4. What is Ofloxacin 200 mg tablet used for? 

It is used to treat bacterial infections like urinary tract infections, respiratory infections, and gastrointestinal infections. 

5. What is the Ofloxacin dosage for stomach infection? 

The usual dose is 200 mg to 400 mg per day in divided doses, as prescribed by the doctor based on severity. 

6. What are the brand names of Ofloxacin? 

Common brand names include zanocin, oflin, ofoxin, and oflomac. At SayaCare we provide the same medicine by its actual medicine name, nothing but a generic medicine, tested in national accreditation board for testing and calibration laboratories (NABL)

7. Can Ofloxacin be used for loose motion? 

Yes, Ofloxacin is used to treat loose motion caused by bacterial infections, but only under a doctor’s advice. 

8. What category does Ofloxacin belong to? 

Ofloxacin belongs to the fluoroquinolone class of antibiotics. 

9. What is the pediatric dose of Cefixime? 

The usual dose is 8 mg/kg/day, given once or in two divided doses, as prescribed by the doctor based on the child’s weight and condition. 

10. What is the price of Cefixime 200 mg tablet? 

Cefixime price at sayacare is about 65 rupees, at sayacare we provide test report with each medicine. Also, at sayacare we provide you with up to 80% less cost than the market. 

1. PubChem. Ofloxacin, D- [Internet]. Nih.gov. PubChem; 2025 [cited 2025 Jul 24]. Available from 
2. PubChem. Cefixime [Internet]. Nih.gov. PubChem; 2019. Available from 
3. Cefixime [Internet]. go.drugbank.com. Available from 
4. Cefixime (oral route) [Internet]. Mayo Clinic. 2024. Available from 
5. Cefixime: Uses, Dosage, Side Effects & Warnings [Internet]. Drugs.com. Available from 
6. Suprax (cefixime) dosing, indications, interactions, adverse effects, and more [Internet]. reference.medscape.com. Available from 
7. Graham DB, Tripp J. Ofloxacin [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2021. Available from 
8. Ofloxacin (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. www.mayoclinic.org. Available from 
9. Ofloxacin Uses, Side Effects & Warnings [Internet]. Drugs.com. Available from