Amlodipine 5 mg + Perindopril 4 mg tablet is used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload. Common side effects of Amlodipine 5 mg + Perindopril 4 mg are headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes. People with serious liver problems, very low blood pressure, or heart issues, or women who are pregnant or breastfeeding, should inform their doctor before using it. Drinking grapefruit juice with this medication makes it stronger and increases side effects, so it’s best skipped. Always store this medicine in a cool, dry place away from sunlight, and keep it in its original packaging. Taking more than 100 mg of this medicine daily can cause overdosing effects like severe hypotension, dizziness, fainting, and potentially life-threatening cardiovascular collapse.

Amlodipine 5 mg + Perindopril 4 mg is used to treat high blood pressure and chest pain related to it.

More Common

1. Headache 
2. Dizziness 
3. Constipation 
4. Skin rash 
5. Decreased blood pressure 
6. Nausea 

Less Common 

1. Lightheadedness 
2. Palpitations 
3. Oedema (accumulation of water in the tissues)

Amlodipine 5 mg + Perindopril 4 mg works by helping the blood vessels relax and widen, which makes it easier for blood to flow and lowers blood pressure. It blocks three types of calcium channels L-type, T-type, and N-type that normally tighten blood vessels and make the heart work harder. It also reduces angiotensin, which causes blood pressure.

Pregnancy

Pregnant women are not recommended to take Amlodipine 5 mg + Perindopril 4 mg, as there are no human studies supporting its safety during pregnancy. In case of an emergency, consult a doctor before using it.

Breastfeeding

Amlodipine 5 mg + Perindopril 4 mg can pass into breast milk, so it’s used with caution during breastfeeding. Other safer options are usually tried first. If it is needed, the baby should be watched closely for any changes like diarrhea or sleepiness. Always talk to your doctor before using it.

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the medicine is converted into a less toxic form in the liver and excreted through the kidney. They may cause interactions and cause severe toxicity, so consult a doctor before using them

Amlodipine 5 mg + Perindopril 4 mg is generally safe with food, and it is recommended to avoid alcohol and smoking with Amlodipine 5 mg + Perindopril 4 mg, as they can alter the drug’s effect and may cause severe drowsiness and sedation because of their direct action on the brain.

Avoid taking Amlodipine 5 mg + Perindopril 4 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Amlodipine-3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Perindopril- 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

Daily dose

Take Amlodipine 5 mg + Perindopril 4 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 200 mg of Amlodipine + Perindopril per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary. 

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take Amlodipine 5 mg + Perindopril 4 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Amlodipine 5 mg + Perindopril 4 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Amlodipine 5 mg + Perindopril 4 mg, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

What is the mechanism of action of Amlodipine 5 mg + Perindopril 4 mg?

mechanism of action works by helping the blood vessels relax and widen, which makes it easier for blood to flow and lowers blood pressure. It blocks three types of calcium channels like L-type, T-type, and N-type that normally tighten blood vessels and make the heart work harder. By easing these signals, Amlodipine 5 mg + Perindopril 4 mg opens the pathways and lightens the heart’s load.

What are the uses of Amlodipine 5 mg + Perindopril 4 mg tablets?

Amlodipine 5 mg + Perindopril 4 mg are medicines used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload.

What are the side effects of Amlodipine 5 mg + Perindopril 4 mg?

Common side effects of Amlodipine 5 mg + Perindopril 4 mg use include headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes.

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