Lisinopril + Amlodipine is an oral medicine belonging to the category of antihypertensives and is used for the following indications: 

1. High blood pressure 
2. Heart Failure 

More Common  

1. Headache
2. Dizziness
3. Cough
4. Low blood pressure
5. Chest pain
6. Swelling of the ankles or feet

Less Common 

1. Arm, back, or jaw pain
2. Chest discomfort, tightness, or heaviness
3. Fast or irregular heartbeat
4. General feeling of discomfort or illness
5. Joint pain
6. Loss of appetite
7. Muscle aches and pains
8. Shivering
9. Trouble sleeping
10. Acid or sour stomach
11. Belching
12. Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
13. Feeling of constant movement of self or surroundings
14. Heartburn
15. Indigestion
16. Muscle cramps
17. Sensation of spinning
18. Stomach discomfort or upset
19. Swelling
20. Decreased interest in sexual intercourse
21. Inability to have or keep an erection
22. Lack or loss of strength
23. Loss in sexual ability, desire, drive, or performance
24. Rash
25. Chest tightness
26. Difficult or labored breathing
27. Dizziness
28. Fast, irregular, pounding, or racing heartbeat or pulse
29. Feeling of warmth
30. Redness of the face, neck, arms, and occasionally, upper chest

Lisinopril and amlodipine work by targeting different pathways to lower blood pressure. Lisinopril blocks the enzyme that produces angiotensin II, a chemical that tightens blood vessels, helping them relax and reducing fluid buildup. Amlodipine stops calcium from entering the vessel walls, keeping arteries open and improving blood flow. Together, they ease strain on the heart, lower blood pressure more effectively, and protect the kidneys.

Pregnancy

Lisinopril is unsafe in pregnancy as it can harm the baby, while amlodipine is used cautiously. Doctors usually recommend switching to safer blood pressure medicines during pregnancy and inform your doctor if you are pregnant.

Breastfeeding

Lisinopril can pass into breast milk and may rarely lower your baby’s blood pressure or cause tiredness. Safer options like enalapril are preferred, and inform your doctor before continuing.

Liver Problems

Lisinopril can worsen kidney problems, while amlodipine may build up in liver disease. Both require caution, so patients should consult a doctor for safe alternatives and dose adjustments.

Lisinopril can interact with potassium‑rich foods, salt substitutes, and alcohol, while amlodipine adds to the blood‑pressure‑lowering effect; together these risks may cause dizziness, low blood pressure, or kidney strain, so it’s essential to consult your doctor and have regular monitoring.

Avoid taking Lisinopril + Amlodipine with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Lisinopril- (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid.

Amlodipine- (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate.

Daily dose

Take Lisinopril + Amlodipine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 40 mg of lisinopril + amlodipine medicine per day, as it may cause severe overdosing effects like kidney and liver damage, dizziness, and severe low blood pressure. If you face any of the severe effects, see the doctor.

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

1. Take lisinopril + amlodipine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking lisinopril + amlodipine without your doctor’s approval, even if you feel better. 
3. If you forget to take lisinopril + amlodipine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Lisinopril + amlodipine is a blood pressure medicine that combines two therapeutic ingredients to relax and widen blood vessels. Lisinopril is an ACE inhibitor that blocks a chemical angiotensin, which tightens vessels, while amlodipine is a calcium gate blocker that eases blood flow by relaxing blood vessels. It helps prevent heart problems, stroke, and kidney damage. Common side effects include dizziness, tiredness, dry cough, and ankle swelling. Inform your doctor if you’re pregnant, breastfeeding, or have kidney issues or past severe allergic reactions. Avoid taking this medicine with alcohol and high-potassium foods (like bananas) , as this can increase risks. Taking more than 40 mg of lisinopril and amlodipine daily can be dangerous,and cause severe hypotension, shock, kidney injury, and life‑threatening complications. Always follow your doctor’s instructions when using it.

What are the uses of the lisinopril and amlodipine combination?

Lisinopril + amlodipine is a blood pressure medicine that combines two drugs to relax and widen blood vessels. Lisinopril is an ACE inhibitor that blocks a chemical that tightens vessels, while amlodipine is a calcium channel blocker that eases blood flow. It helps prevent heart problems, stroke, and kidney damage.

What is the price of the amlodipine-lisinopril combination pill?

At Saya Care, a pack of 10 tablets, each tablet containing lisinopril 5 mg + amlodipine 5 mg, costs around 20 rupees, which is 80% less than the market price

What are the side effects of the lisinopril and amlodipine combination?

Common side effects of lisinopril + amlodipine include dizziness, tiredness, dry cough, and ankle swelling. Avoid if you’re pregnant, breastfeeding, or have kidney issues or past severe allergic reactions.

What is the drug class of lisinopril?

Lisinopril is an antihypertensive drug belonging to the class of angiotensin-converting enzyme inhibitors.

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