Tranexamic Acid 500 mg + Mefenamic Acid 250 mg is a combination medicine mainly used to treat heavy menstrual bleeding, painful periods, menstrual cramps, and excess bleeding during menstruation. Tranexamic acid helps reduce heavy bleeding by preventing blood clots from breaking down too quickly, while mefenamic acid helps relieve pain, cramps, and swelling by blocking certain chemicals in the body that cause pain and inflammation. Together, they help control both heavy bleeding and period pain, making periods more manageable and comfortable. Common side effects may include nausea, stomach pain, vomiting, loose motions, indigestion, headache, and dizziness. It is usually taken during periods as advised by the doctor, preferably after food to help reduce stomach upset. 

Tranexamic Acid 500 mg + Mefenamic Acid 250 mg tablets is a combination medicine belong to NSAID class, and it is used to treat in the following conditions: 

1. Heavy menstrual bleeding 
2. Painful periods   

More Common  

1. Nausea 
2. Stomach pain 
3. Vomiting 
4. Loose motions (diarrhea) 
5. Indigestion 
6. Headache 
7. Dizziness    

Less Common 

1. Skin rash 
2. Acidity or heartburn 
3. Constipation 
4. Blurred vision 
5. Swelling in hands or feet 
6. Allergic reaction (rare) 
7. Blood clot-related problems )   

This medicine works in two ways to help during periods. Tranexamic acid helps reduce heavy bleeding by stopping the breakdown of blood clots, which helps control excess blood loss. Mefenamic acid helps relieve period pain by blocking certain chemicals in the body that cause pain, swelling, and cramps. Together, they help reduce both heavy bleeding and painful cramps during menstruation. 

Allergy or Hypersensitivity

If you are allergic to this medicine or any ingredients in this medicine, consult your doctor before taking it because it can cause serious allergic reactions like rash, swelling, or trouble breathing. 

Kidney problems

If you have kidney disease, consult your doctor before taking this medicine because it can worsen kidney function and cause the medicine to build up in the body.

Liver problems

If you have liver disease, consult your doctor before taking this medicine because it can increase the risk of side effects and may worsen liver problems.

Stomach ulcer or stomach bleeding

If you have a stomach ulcer, acidity, or bleeding in the stomach, consult your doctor before taking this medicine because it can increase stomach irritation and raise the risk of bleeding.

History of blood clots

If you have a history of blood clots, stroke, deep vein thrombosis (DVT), or clotting problems, consult your doctor before taking this medicine because it can increase the risk of dangerous blood clots.

Asthma

If you have asthma, especially after taking painkillers, consult your doctor before taking this medicine because it can trigger breathing problems.

Heart disease

If you have heart disease or high blood pressure, consult your doctor before taking this medicine because it can increase the risk of heart-related side effects or fluid retention. 

This medicine can be taken after food to help reduce stomach upset. It is best to avoid or limit alcohol while taking this medicine because it can increase stomach irritation and may raise the risk of stomach bleeding. Very spicy, oily, or heavy meals may also cause more stomach discomfort in some people. 

Avoid taking Tranexamic Acid 500 mg + Mefenamic Acid 250 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Tranexamic Acid: 4-(aminomethyl)cyclohexane-1-carboxylic acid 

Mefenamic Acid: 2-(2,3-dimethylanilino)benzoic acid 

Daily dose

Take Tranexamic Acid 500 mg + Mefenamic Acid 250 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

it is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children. 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

What are the uses of Tranexamic Acid tablets? 

Tranexamic Acid tablets are used to reduce heavy bleeding, especially heavy menstrual bleeding, and may also be used to help control bleeding after surgery, nosebleeds, or other bleeding conditions as advised by the doctor. 

What is the mechanism of action (MOA) of Tranexamic Acid? 

Tranexamic Acid works by preventing blood clots from breaking down too quickly, which helps reduce or control excess bleeding. 

What are the uses of Mefenamic Acid tablets?  

Mefenamic Acid tablets are used to treat menstrual pain (period pain), mild to moderate body pain, headache, toothache, muscle pain, joint pain, back pain, inflammation, and fever.  

How many times a day should Mefenamic Acid be taken?  

Mefenamic Acid is usually taken 2 to 3 times a day, as prescribed by the doctor. It should be taken after food to reduce stomach irritation, and the exact dose depends on the patient’s condition and age.  

What is the mechanism of action of Mefenamic Acid?  

Mefenamic Acid works by blocking cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins chemicals in the body that cause pain, inflammation, and fever.  

Can Mefenamic Acid be used during pregnancy?  

Mefenamic Acid is not recommended during pregnancy, especially in the last 3 months, as it may harm the unborn baby. It should only be used if clearly prescribed by a doctor.   

What is the drug class of Mefenamic Acid?  

Mefenamic Acid belongs to the class of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). 

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