Omeprazole 20 mg+ domperidone 10 mg is taken orally. It is approved for the treatment of heartburn, peptic ulcer, and chronic superficial gastritis. 

You should take this medicine as instructed by your doctor, either before or after meals, or before or after sleep. Side effects of this medicine may include diarrhea, stomach pain, dryness in mouth, headache, and flatulence. Do not stop taking this medicine unless advised by your doctor. 

Inform your doctor if you are allergic or have a peptic ulcer, as they may prescribe an alternative medication in such cases. 

Omeprazole 20 mg+ domperidone 10 mg is an oral medicine. It is used for following indications: 

1. Heart burn (Gastroesophageal reflux disease) 
2. Peptic ulcer 
3. Swelling in upper part of stomach (Chronic superficial gastritis) 

1. Take omeprazole + domperidone exactly as prescribed by your doctor, regularly at the same time each day. 
2. Do not stop taking omeprazole + domperidone without your doctor’s approval, even if you feel better. 
3. If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it. 

Common

1. Diarrhea 
2. Stomach pain 
3. Dryness in mouth 
4. Headache 
5. Farting/Flatulence 
6. Growth of extra mass of tissue in the upper part of the stomach (fundic gland polyps) 

When we eat food, our stomach releases acid. In some individuals, this acid is released in excess amounts, affecting the body’s food pipe (esophagus). To treat this condition, Domperidone and Omeprazole are designed to work together as a team. Omeprazole first acts as a band-aid and closes acid production gate in the stomach, while Domperidone increases the downward movement of food. In this way, they reduce excessive acid production in the stomach. 

Allergy/ Hypersensitivity

If you have an allergy to domperidone or omeprazole, inform your doctor immediately to avoid or prevent any complication.

Kidney Disease

If you have pre-existing kidney disease, inform your physician, as they may adjust the dose or decide not to prescribe the medication.

Liver Disease

Domperidone and omeprazole should be avoided in patients with liver disease, as it can be harmful to the liver.

Pregnancy

Omeprazole crosses the placenta, but it does not harm the fetus; therefore, it is considered safe to use during pregnancy.

Low Mineral Count

If you have low blood potassium, magnesium, or calcium levels, inform your doctor immediately.

Avoid taking domperidone and omeprazole with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Avoid drinking alcohol and grapefruit juice or eating grapefruit while taking this medicine, as they can reduce its effectiveness. 

1. The medicine should be stored at room temperature  
2. Keep away from sunlight and moisture  
3. Keep away from the reach of children 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name- 

Omeprazole- 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole 

Domperidone- 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one 

Daily dose

Take Omeprazole + domperidone exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Take more than the recommended dose of this medicine (2400 mg for omeprazole and 30 mg for domperidone). You may experience symptoms such as blurred vision, confusion, dry mouth, flushing, headache, increased sweating, difficulty speaking, disorientation, dizziness, fainting, irregular heartbeat, light-headedness, and loss of balance or muscle control. If you experience any of these symptoms, or if someone you know who is taking omeprazole exhibits these symptoms, seek medical attention immediately.

1- Can omeprazole and domperidone be taken together? 

Yes, omeprazole and domperidone can be taken together, but only as prescribed by your doctor. Alternatively, you can opt for a single medicine that combines both salts, available from SayaCare at an 80% discount. 

2- What is omeprazole and domperidone capsules used for? 

Omeprazole and domperidone capsules are used to treat peptic ulcers, gastroesophageal reflux disease (GERD), and chronic superficial gastritis. Omeprazole acts like a bottle cap, blocking acid secretion, while domperidone enhances gastric motility, helping move food downward in the digestive tract. 

3- Which one is better generic omeprazole+ domperidone or branded omeprazole + domperidone? 

Generic and branded medicines contain the same active salts and provide the same effectiveness. However, one should not assume that branded medicines are always superior, as many fail to meet CDSCO quality standards. At SayaCare, we ensure that every medicine is thoroughly tested to guarantee its quality, ensuring that every pill adds value to your life. 

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2. Rochester (MN): Mayo Foundation for Medical Education and Research; [cited 2025 Mar 12]. Click here
3. Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007 Sep;102(9):2036-45. doi: 10.1111/j.1572-0241.2007.01255.x. Epub 2007 May 3. PMID: 17488253. Click here
4. Shah N, Gossman W. Omeprazole. [Updated 2023 Feb 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539786/. Click here