This tablet consists of Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) used to treat acid reflux, ulcers, and indigestion (dyspepsia). It works in two different ways where esomeprazole blocks acid secretion, and domperidone improves gut motility and mood by acting on dopamine receptors. Common side effects of Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) are headaches, dizziness, diarrhea, constipation, and sleepiness. Taking this Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) with alcohol and a high-fat meal worsens side effects. People with epilepsy, severe psychiatric illness, pregnancy, or lactation should avoid it. Taking more than 600 mg of this medicine can cause severe drowsiness, tremors, irregular heartbeat, seizures, and collapse.

Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) is used for the following indications:

1. Dyspepsia (indigestion) 
2. Gastroesophageal reflux disease (GERD) 
3. Irritable bowel syndrome (IBS) 
4. Ulcers 

More Common

1. Drowsiness 
2. Breast tenderness 
3. Irregular menstrual periods 
4. Constipation 
5. Weight gain 
6. Unusual tiredness and weakness 

Less Common 

1. Tremors  
2. Dystonia 
3. Akathisia 
4. Dyskinesia 
5. Seizures 
6. Agitation 
7. Insomnia 
8. Galactorrhea 
9. Gynecomastia 
10. Amenorrhea 
11. Arrhythmia 
12. Hypotension 
13. Photosensitivity 
14. Pruritus 
15. Rash 

Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) works in two ways in which, Domperidone helps the stomach push food forward by calming excessive dopamine signals. Esomeprazole lowers stomach acid by turning off the acid pump in stomach cells. Together they ease digestion and reduce burning or discomfort from acid reflux.

Pregnancy

The safety of this medicine in pregnancy is not established. Inform your doctor if you are pregnant or planning to conceive.

Breastfeeding

This medicine is not usually recommended during breastfeeding because there is no reliable information on whether it passes into breast milk or how it might affect a nursing infant.

Kidney and Liver Problems

This medicine is known to be safe for use in liver and kidney disease patients.

Past Mental Health Problems

Domperidone directly acts on the brain and causes different side effects like sedation, drowsiness, and suicidal thoughts. Inform the doctor about your past mental health issues before using Domperidone.

Heart Problems

This medicine should be used with caution in heart patients, as it can affect blood vessel tone and, in rare cases, affect heart rhythm or blood pressure.

Avoid consuming alcohol and smoking simultaneously together, as it may affect the drug’s action and show an effect on the brain, leading to severe drowsiness, sedation, and coma in severe cases.

Avoid taking Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Domperidone- N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide 

Esomeprazole-(S)-5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-3H-benzimidazole. 

Daily dose

Take Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 600 mg of domperidone + esomeprazole per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary.

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

1. Take Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) without your doctor’s approval, even if you feel better. 
3. If you forget to take Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC), take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

What are the uses of Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) tablets?

Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) tablets are used to treat indigestion, bloating, acid reflux, and delayed stomach emptying. They are also prescribed for depression, anxiety, and certain psychotic disorders due to their dopamine-blocking effects.

What are the side effects of Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) tablets?

Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) tablets may cause drowsiness, dizziness, breast swelling, menstrual changes, or movement issues like tremors. Rarely, it can lead to hormonal imbalances or heart rhythm problems with long-term use.

What is the drug class of Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC)?

Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) belongs to the drug class of calcium channel blockers and can show vascular effects.

What is the highest dose of Domperidone + Esomeprazole?

Domperidone 30 mg (SR) + Esomeprazole 40 mg (EC) is usually prescribed up to 600 mg/day, with 300 mg/day as the upper limit in psychiatric use. Exceeding this increases the risk of side effects, so dosing must always be guided by a physician.

1. Drugs.com. Esomeprazole: Uses, Dosage, Side Effects. [Internet]. Drugs.com; c1996–2026 [cited 2026 Jan 3]. Available from. 
2. Practo. Esomeprazole: Uses, Dosage, Side Effects, Price. [Internet]. Practo Technologies Pvt. Ltd.; c2008–2026 [cited 2026 Jan 3]. Available from. 
3. Mayo Clinic. Esomeprazole (oral route) – Side effects & dosage. Mayo Clinic [Internet]. 2025 Dec 1 [cited 2026 Jan 3]. Available from. 
4. National Center for Biotechnology Information. PubChem Compound Summary for CID 957740, Esomeprazole. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2026 Jan 3]. Available from. 
5. Drugs.com. Domperidone: Uses, Dosage, Side Effects, Warnings [Internet]. Drugs.com; 2025 Mar 25 [cited 2026 Mar 9]. Available from. 
6. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3151, Domperidone; [cited 2026 Mar. 9]. Available from.