Losartan 50 mg + Hydrochlorothiazide 12.5 mg is a combination medicine used to treat high blood pressure (hypertension). Losartan is an angiotensin II receptor blocker (ARB) that helps relax blood vessels, while hydrochlorothiazide is a diuretic (water pill) that helps the kidneys remove excess salt and water from the body. Together, they help lower blood pressure and improve blood pressure control. 

This medicine should be taken only as prescribed by a doctor. Do not use it if you are allergic to losartan, hydrochlorothiazide, or any of its ingredients.  

Losartan 50 mg and Hydrochorthaizide 12.5 mg tablet is used to treat high blood pressure     

More Common

1. Dizziness 
2. Headache 
3. Tiredness 
4. Increased urination 
5. Low blood pressure          

Less Common 

1. Nausea 
2. Diarrhea 
3. Muscle cramps 
4. Weakness 
5. Changes in potassium or sodium levels 
6. Increased sensitivity to sunlight        

Losartan blocks the action of angiotensin II, a substance that causes blood vessels to narrow. This helps relax the blood vessels and lower blood pressure. Hydrochlorothiazide increases the removal of excess salt and water through urine, which helps reduce the amount of fluid in the blood vessels and lowers blood pressure. Together, they provide better blood pressure control.

Allergy or Hypersensitivity

Inform your doctor if you are allergic to losartan, hydrochlorothiazide, sulfonamide-related medicines, or any other medicines.

Low Blood Pressure

This medicine may cause dizziness or low blood pressure, especially when treatment is started or the dose is increased. Rise slowly from sitting or lying down.

Kidney Problems

Tell your doctor if you have kidney disease. Your doctor may monitor kidney function and electrolyte levels during treatment.

Liver Problems

Inform your doctor if you have liver disease, as your treatment may need closer monitoring.

Electrolyte Imbalance

Hydrochlorothiazide can affect potassium, sodium, and other electrolyte levels. Tell your doctor if you experience unusual weakness, muscle cramps, confusion, or an irregular heartbeat.

Diabetes

This medicine may affect blood sugar levels. If you have diabetes, monitor your blood glucose as advised by your doctor.

Gout

Hydrochlorothiazide may increase uric acid levels and can worsen gout in some people. Inform your doctor if you have a history of gout.

Pregnancy

Losartan should not be used during pregnancy because this medicine can harm the developing baby. Inform your doctor if you are pregnant or planning pregnancy.

Dehydration

Excessive fluid loss from vomiting, diarrhea, heavy sweating, or inadequate fluid intake may increase the risk of low blood pressure or kidney problems. Inform your doctor if you become severely dehydrated.

This medicine can generally be taken before or after food. Avoid excessive alcohol consumption because it may increase dizziness or lower blood pressure. 

Avoid taking Losartan 50 mg and Hydrochorthaizide 12.5 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Losartan: [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl) phenyl] phenyl] methyl] imidazol-4-yl] methanol 

Hydrochorthaizide: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide 

Daily dose

Take Losartan 50 mg and Hydrochorthaizide 12.5 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

An overdose may cause very low blood pressure, dizziness, excessive urination, dehydration, weakness, changes in electrolyte levels, or loss of consciousness. Seek immediate medical attention if an overdose is suspected.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.    

What are the major side effects reported for losartan and hydrochlorothiazide combinations? 

Common side effects include dizziness, headache, tiredness, increased urination, nausea, and low blood pressure. It may also cause changes in potassium or sodium levels. If you experience severe dizziness, fainting, or unusual weakness, contact your doctor.

How do I check the authenticity of losartan and hydrochlorothiazide medicines bought online? 

Check the medicine name, strength, manufacturer, batch number, manufacturing date, expiry date, and packaging. Make sure the pack is sealed and does not look damaged or tampered with. Buy only from a reliable online pharmacy and check that the medicine matches your prescription.

Where can I buy losartan and hydrochlorothiazide combination tablets online in India? 

You can buy losartan and hydrochlorothiazide combination tablets online in India from SayaCare. Select the prescribed medicine and strength, upload your prescription when required, and place your order for delivery. Always check that the medicine and strength match your doctor’s prescription. 

When is the best time to take losartan potassium and hydrochlorothiazide? 

It can be taken before or after food, usually once a day at the same time each day. Because hydrochlorothiazide increases urination, morning is often a convenient time to take it, rather than close to bedtime. Follow the timing prescribed by your doctor. 

Can you take losartan and hydrochlorothiazide together? 

Yes. Losartan and hydrochlorothiazide are commonly prescribed together as a combination medicine for high blood pressure. The usual combination is losartan 50 mg + hydrochlorothiazide 12.5 mg, taken once daily when prescribed by a doctor. 

Reference  

1. PubChem. Losartan [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Aug 17]. Available from 
2. PubChem. Hydrochlorothiazide [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Aug 18]. Available from 
3. Losartan And Hydrochlorothiazide (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. www.mayoclinic.org. [cited 2026 Aug 18]. Available from 
4. Losartan; Hydrochlorothiazide Tablets [Internet]. Cleveland Clinic. [cited 2026 Aug 18]. Available from 
5. Losartan and Hydrochlorothiazide | Memorial Sloan Kettering Cancer Center [Internet]. www.mskcc.org. [cited 2026 Aug 18]. Available from