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Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg tablet is mainly used to lower high blood pressure and reduce swelling. Doctors prescribe it for kidney stones and to normalize blood pressure. It works by reducing the pressure on heart and helping the body flush out extra salt and water, which eases pressure on blood vessels. Common side effects include frequent urination, dizziness, headache, tiredness, nausea, constipation, low potassium, sensitivity to sunlight, gout, and higher blood sugar. Alcohol, painkillers like NSAIDs, and lithium can interfere with its effect, while a low-salt diet or potassium supplements may be advised. Extra care is needed in older adults and people with diabetes, gout, or liver and kidney problems. Taking too more than 40 mg can be dangerous, causing severe dehydration, very low blood pressure, salt imbalance, and irregular heartbeat that require urgent medical care.
| Uses | 1. To treat high blood pressure 2. To prevent heart attacks. |
| Common Side Effects | 1. Headache 2. Dizziness 3. Constipation 4. Skin rash 5. Decreased blood pressure 6. Nausea |
| Additional Information | 1. Take medicine every day at the same time to maintain the drug well in the blood. 2. Do not stop the medicine usage suddenly |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medicine orally with a sip of water |
Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is used to prevent high blood pressure and heart attacks.
Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is a combination of hydrochlorothiazide and Bisoprolol. Here hydrochlorothiazide relaxes and widens blood vessels, making it easier for blood to flow and lowering pressure. Bisoprolol slows down the heart rate and reduces the force of pumping, easing strain on the heart. Together, they help control high blood pressure and protect the heart from overwork.
Pregnant women are not recommended to take Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg, as there are no human studies supporting its safety during pregnancy. In case of an emergency, consult a doctor before using it.
Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg can pass into breast milk, so it’s used with caution during breastfeeding. Other safer options are usually tried first. If it is needed, the baby should be watched closely for any changes like diarrhea or sleepiness. Always talk to your doctor before using it.
Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the medicine is converted into a less toxic form in the liver and excreted through the kidney. They may cause interactions and cause severe toxicity, so consult a doctor before using it.
Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is generally safe with food, and it is recommended to avoid alcohol and smoking with Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg, as they can alter the drug’s effect and may cause severe drowsiness and sedation because of their direct action on the brain.
Avoid taking Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Hydrochlorothiazide- 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Bisoprolol-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

Take Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
It is not recommended to take more than 600 mg of this medicine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary.
Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is a combination of hydrochlorothiazide and bisoprolol. Here Amlodipine relaxes and widens blood vessels, making it easier for blood to flow and lowering pressure. Bisoprolol slows down the heart rate and reduces the force of pumping, easing strain on the heart. Together, they help control high blood pressure and protect the heart from overwork.
Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg are medicines used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload.
Common side effects of Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg use include headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes.

Written By-
Siva Krishna Adithya BhumireddyMedical content writer
Bachelors in Pharmacy | 1+ Year experience

Reviewed By-
Mahak PhartyalMedical Content writer and reviewer
Bachelors in Pharmacy | 3+ Year experience
Last Updated: 22 Sep 2026
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