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Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg | Tablet

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Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg | Tablet

Drug Code: 453

| tablettablet| Pack of 10 tablets
MRP ₹72.66

₹28

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Batch Details

Composition

bisoprolol 5 mg + hydrochlorothiazide 6.25 mg

Batch

66|BAT072601

Expiry

June 2028

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Batch Details

Composition

bisoprolol 5 mg + hydrochlorothiazide 6.25 mg

Batch

66|BAT072601

Expiry

June 2028

About Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg tablet is mainly used to lower high blood pressure and reduce swelling. Doctors prescribe it for kidney stones and to normalize blood pressure. It works by reducing the pressure on heart and helping the body flush out extra salt and water, which eases pressure on blood vessels. Common side effects include frequent urination, dizziness, headache, tiredness, nausea, constipation, low potassium, sensitivity to sunlight, gout, and higher blood sugar. Alcohol, painkillers like NSAIDs, and lithium can interfere with its effect, while a low-salt diet or potassium supplements may be advised. Extra care is needed in older adults and people with diabetes, gout, or liver and kidney problems. Taking too more than 40 mg can be dangerous, causing severe dehydration, very low blood pressure, salt imbalance, and irregular heartbeat that require urgent medical care.

Medicine Highlights

Uses 1. To treat high blood pressure 
2. To prevent heart attacks. 
Common Side Effects  1. Headache 
2. Dizziness 
3. Constipation 
4. Skin rash 
5. Decreased blood pressure 
6. Nausea 
Additional Information 1. Take medicine every day at the same time to maintain the drug well in the blood. 
2. Do not stop the medicine usage suddenly 
Storage 1. The medicine should be stored at room temperature.  
2. Keep away from sunlight and moisture.  
3. Keep away from the reach of children 
How to Take This MedicineTake this medicine orally with a sip of water

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg Uses

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is used to prevent high blood pressure and heart attacks.

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg side effects

More Common

  1. Headache 
  2. Dizziness 
  3. Constipation 
  4. Skin rash 
  5. Decreased blood pressure 
  6. Nausea 

Less Common 

  1. Lightheadedness 
  2. Palpitations 
  3. Oedema (accumulation of water in the tissues) 

How Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg works

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is a combination of hydrochlorothiazide and Bisoprolol. Here hydrochlorothiazide relaxes and widens blood vessels, making it easier for blood to flow and lowering pressure. Bisoprolol slows down the heart rate and reduces the force of pumping, easing strain on the heart. Together, they help control high blood pressure and protect the heart from overwork.

Safety Measures and Warning

Pregnancy

Pregnant women are not recommended to take Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg, as there are no human studies supporting its safety during pregnancy. In case of an emergency, consult a doctor before using it.

Breastfeeding

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg can pass into breast milk, so it’s used with caution during breastfeeding. Other safer options are usually tried first. If it is needed, the baby should be watched closely for any changes like diarrhea or sleepiness. Always talk to your doctor before using it.

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the medicine is converted into a less toxic form in the liver and excreted through the kidney. They may cause interactions and cause severe toxicity, so consult a doctor before using it.

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg Interaction with Food Product

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is generally safe with food, and it is recommended to avoid alcohol and smoking with Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg, as they can alter the drug’s effect and may cause severe drowsiness and sedation because of their direct action on the brain.

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg Interaction with Other Medicines

Avoid taking Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Hydrochlorothiazide- 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg

Bisoprolol-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg

Intake routine/cycle

Daily dose

Take Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 600 mg of this medicine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary.

Storage

  1. Store the medicine at room temperature. 
  2. Keep away from sunlight and moisture. 
  3. Keep out of reach of children 

Directions for use

  1. Take Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg exactly as prescribed by your doctor, at the same time each day. 
  2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
  3. If you forget to take this medicine, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

FAQ’s

What is the mechanism of action of Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg?

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg is a combination of hydrochlorothiazide and bisoprolol. Here Amlodipine relaxes and widens blood vessels, making it easier for blood to flow and lowering pressure. Bisoprolol slows down the heart rate and reduces the force of pumping, easing strain on the heart. Together, they help control high blood pressure and protect the heart from overwork.

What are the uses of Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg tablets?

Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg are medicines used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload.

What are the side effects of the Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg tablets?

Common side effects of Bisoprolol 5 mg + Hydrochlorothiazide 6.25 mg use include headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes.

Reference

  1. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–.Hydrochlorothiazide. Available from.  
  2. Cerner Multum. Hydrochlorothiazide: Uses, Side Effects & Warnings [Internet]. Drugs.com; 2026 Mar 21 [cited 2026 Aug 13]. Available from.  
  3. Mayo Clinic Staff. Hydrochlorothiazide 6.25 mg (oral route) [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; c2026 [cited 2026 Aug 13]. Available from.  
  4. National Center for Biotechnology Information. PubChem Compound Summary for CID 3639, Hydrochlorothiazide [Internet]. Bethesda (MD): National Library of Medicine; [cited 2026 Aug 13]. Available from.  
  5. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004–. PubChem Compound Summary for CID 2405, Bisoprolol [cited 2026 Aug 13]. Available from.  
  6. Mayo Clinic [Internet]. Bisoprolol (oral route). Rochester (MN): Mayo Foundation for Medical Education and Research; c2026 [cited 2026 Aug 13]. Available from.  
  7. Drugs.com [Internet]. Bisoprolol. [cited 2026 Aug 13]. Available from.  

Siva Krishna Adithya Bhumireddy avatar

Written By-

Siva Krishna Adithya Bhumireddy

Medical content writer

Bachelors in Pharmacy | 1+ Year experience

Mahak Phartyal avatar

Reviewed By-

Mahak Phartyal

Medical Content writer and reviewer

Bachelors in Pharmacy | 3+ Year experience

Last Updated: 22 Sep 2026

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