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Hydroquinone + Mometasone + Tretinoin cream is a combination skin medicine mainly used to treat melasma, dark spots, pigmentation, and uneven skin tone on the face. Hydroquinone helps lighten dark patches by reducing the formation of skin pigment, tretinoin helps remove old, pigmented skin cells and promotes new skin cell growth, and mometasone helps reduce redness, swelling, and irritation. Together, they help improve dark patches and make the skin tone look more even. Common side effects may include burning, redness, itching, dryness, peeling, and irritation. This cream should be used only for a short period as advised by the doctor, along with sunscreen during the day.
| Uses | 1. To treat melasma (dark patches on the skin) 2. To treat skin pigmentation 3. To treat dark spots on the face 4. To help lighten uneven skin tone |
| Common Side Effects | 1. Burning sensation 2. Redness 3. Itching 4. Skin irritation 5. Dryness 6. Peeling of skin 7. Mild stinging |
| Additional Information | 1. Take it exactly as prescribed by your doctor. 2. Avoid smoking, as it can reduce the medicine’s effect. 3. Inform your doctor if you have heart, liver, or kidney problems. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Apply a thin layer of the cream on the affected skin only. |
Hydroquinone 2% + Mometasone 0.1% + Tretinoin 0.025% cream is a combination skin medicine used to treat the following conditions:
Hydroquinone 2% + Mometasone 0.1% + Tretinoin 0.025% cream works in three ways to help reduce dark patches on the skin. Hydroquinone helps lighten the skin by reducing the production of melanin, a protein responsible for the dark spots. Tretinoin helps remove old, pigmented skin cells and supports new skin cell growth, which improves skin tone. Mometasone is a steroid that helps reduce redness, swelling, and irritation caused by other ingredients. Together, they help fade pigmentation and improve the appearance of the skin.
If you are allergic to this medicine ie consult your doctor before using it because it can cause serious allergic reactions like rash, swelling, severe itching, or irritation.
If you have very sensitive skin, cuts, wounds, sunburn, or damaged skin, consult your doctor before using this medicine because it can cause severe burning, irritation, and worsening of skin damage.
If you have eczema, severe skin allergy, or skin rash, consult your doctor before using this medicine because it can make irritation worse and may not be suitable.
If you have a fungal, bacterial, or viral skin infection, consult your doctor before using this medicine because the steroid part can hide the infection and make it worse.
There are no major food interactions with this cream because it is applied on the skin. However, avoid alcohol-based skin products, harsh scrubs, strong soaps, and other irritating skincare products while using it, as they can increase burning, dryness, and skin irritation. Also avoid direct sunlight and always use sunscreen during the day.
Avoid taking Hydroquinone 2% + Mometasone 0.1% + Tretinoin 0.025% with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Hydroquinone: benzene-1,4-diol

Mometasone: (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Tretinoin: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid

Take Hydroquinone 2% + Mometasone 0.1% + Tretinoin 0.025% exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
it is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.
Hydroquinone cream is used to treat melasma, dark spots, skin pigmentation, acne marks, and uneven skin tone.
Common side effects of Hydroquinone cream may include burning, redness, itching, dryness, mild irritation, and peeling of the skin.
Mometasone cream is used to treat skin redness, itching, swelling, eczema, dermatitis, and allergic skin conditions.
Common side effects of Mometasone cream may include burning, itching, dryness, irritation, skin thinning, and acne-like eruptions with long-term use.
Tretinoin cream is used to treat acne, acne marks, dark spots, skin pigmentation, fine lines, and uneven skin tone.
Common side effects of Tretinoin cream may include redness, dryness, peeling, burning, stinging, irritation, and increased sensitivity to sunlight.


Reviewed By-
Mahak PhartyalMedical Content writer and reviewer
Bachelors in Pharmacy | 3+ Year experience
Last Updated: 09 Jul 2026
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