Doxofylline 400 mg + Ambroxol 30 mg tablet is a combination medicine commonly used to help manage breathing conditions associated with narrowed airways and excess mucus, as recommended by a doctor. Doxofylline helps relax the muscles around the airways, making it easier to breathe. Ambroxol helps thin and loosen mucus, making it easier to cough out. Take this medicine exactly as prescribed. Do not increase the dose or use it for longer than recommended.   

Doxofylline 400 mg + Ambroxol 30 mg is used to manage breathing difficulty caused by narrowed airways in the following conditions: 

1. Asthma, chronic obstructive pulmonary disorder (COPD) 
2. Chronic bronchitis and emphysema  
3. Wet or productive cough with excess mucus   

More Common

1. Nausea 
2. Vomiting 
3. Stomach discomfort 
4. Headache 
5. Dizziness 
6. Dry mouth 
7. Diarrhea 
8. Restlessness 
9. Difficulty sleeping              

Less Common 

1. Fast or irregular heartbeat 
2. Palpitations 
3. Tremors or shakiness 
4. Skin rash 
5. Itching 
6. Increased stomach discomfort            

This medicine contains two ingredients, doxofylline and ambroxol. Doxofylline widens the airways, resulting in the easy passage of air into and out of the lungs. Ambroxol helps loosen mucus in the airways. This makes the mucus easier to cough out and helps clear the airways. Together, they help improve airflow and make it easier to clear mucus from the respiratory tract. 

Allergy or Hypersensitivity

If you are allergic to Doxofylline, Ambroxol, or any other ingredient in this medicine, tell your doctor before taking it. This medicine may cause an allergic reaction in sensitive individuals.

Heart problems

 If you have heart disease, an abnormal heart rhythm, or high blood pressure, tell your doctor before taking this medicine. Doxofylline may affect heart rate and may require closer monitoring.

Seizures

If you have epilepsy or a history of seizures, tell your doctor before taking this medicine. Doxofylline may increase the risk of seizures in some people.

Liver problems

If you have liver disease, tell your doctor before taking this medicine. Your doctor may need to monitor you more closely or adjust your treatment.

Kidney problems

If you have kidney disease, tell your doctor before taking this medicine. Your doctor may need to consider your kidney function when deciding your treatment.

Stomach ulcers

 If you have a history of stomach ulcers or other stomach problems, tell your doctor before taking this medicine. Doxofylline may cause or worsen stomach discomfort in some people.

Pregnancy

If you are pregnant or planning to become pregnant, tell your doctor before taking this medicine. Your doctor will decide whether this medicine is suitable for you during pregnancy.

Breastfeeding

If you are breastfeeding, tell your doctor before taking this medicine. Your doctor will decide whether this medicine is suitable for you and your baby.

Sudden breathing problems

If you have sudden or severe breathing difficulty, seek immediate medical attention rather than relying on this medicine for quick relief. This medicine may not provide rapid relief during a severe asthma attack.

Take the medicine as directed by your doctor. Avoid excessive caffeine-containing drinks such as coffee, tea, energy drinks, or cola if they make you feel restless, shaky, or cause a fast heartbeat. Avoid alcohol if it makes you feel dizzy or unwell. 

Avoid taking Doxofylline 400 mg + Ambroxol 30 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Doxofylline: 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione

Ambroxol: 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol

Daily dose

Take Doxofylline 400 mg + Ambroxol 30 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Taking more than the prescribed amount may cause nausea, stomach discomfort, diarrhea, dizziness, restlessness, or mood changes. If you suspect an overdose, contact your doctor or seek immediate medical attention.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.     

What are the uses of a combined doxofylline and ambroxol tablet? 

Doxofylline and ambroxol combination tablets are used to loosed mucus stuck in the airways, making it easier to breathe.

What are the side effects of a medication containing doxofylline and ambroxol? 

Common side effects of medicine containing doxofylline and ambroxol may include nausea, vomiting, stomach discomfort, headache, dizziness, diarrhoea, restlessness, or difficulty sleeping. Contact your doctor if these effects are severe or do not improve. 

How does the combination of doxofylline and ambroxol work for breathing problems? 

Doxofylline helps relax the muscles around the airways, making it easier to breathe. Ambroxol helps thin and loosen mucus so it can be coughed out more easily. Together, they help improve airflow and clear mucus from the airways.

Where can I buy doxofylline and ambroxol tablets online in India? 

You can buy doxofylline and ambroxol tablets online from a reliable pharmacy such as SayaCare. Check the prescription requirements before ordering and use the medicine only as directed by your doctor. 

What precautions should I take when using doxofylline and ambroxol tablets? 

Tell your doctor if you have heart problems, high blood pressure, seizures, stomach ulcers, thyroid problems, or liver or kidney disease. Also inform your doctor if you are pregnant, breastfeeding, or taking other medicines. Limit excessive caffeine and seek medical attention if you develop a severe skin rash or worsening breathing problems.

Reference  

1. PubChem. Doxofylline [Internet]. Nih.gov. PubChem; 2024 [cited 2026 Sept 17]. Available from 
2. PubChem. Ambroxol [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 17]. Available from