Dapagliflozin 10 mg + Sitagliptin 100 mg are tablet medicines used for type 2 diabetes. Here, dapagliflozin Helping the body pee out extra sugar, while sitagliptin boosts insulin release by protecting pancreatic hormones. This combination lowers sugar levels and may help with weight loss and is easy to take. Food has minimal impact, but staying hydrated and avoiding heavy fatty meals is advised. Patients older than 60 years, with kidney or liver impairment, and dehydrated patients should consult a doctor before taking this medication. The maximum daily dose of Dapagliflozin 10 mg + Sitagliptin 100 mg is 300 mg of sitagliptin. Taking more than 300 mg of Dapagliflozin 10 mg + Sitagliptin 100 mg cause overdose effects like dehydration or organ dysfunction.

Dapagliflozin 10 mg + sitagliptin 100 mg is an oral combination medicine belonging to the category of antidiabetic drugs and is used to manage type 2 diabetes mellitus.

More Common

1. Headache  
2. Cough  
3. Constipation  
4. Excessive sweating  
5. Weakness  
6. Thirst  
7. Dizziness  
8. Increased Urine

Less Common 

1. Hypoglycemia (especially when used with other medications) 
2. Swelling of the face, lips, or eyelids 
3. Heartburn 
4. Liver enzyme elevation 
5. Burning or pain while peeing 
6. Itchy skin 
7. Skin rash 

Dapagliflozin 10 mg + Sitagliptin 100 mg work by tackling high blood sugar from two angles in type 2 diabetes; dapagliflozin blocks SGLT2 channels in the kidneys, allowing excess glucose to exit through urine, while sitagliptin protects pancreatic hormones that help the pancreas release insulin. This dual action controls sugar without weight gain and may even help with slight weight loss.

Pregnancy

Due to a lack of studies on the effects of Dapagliflozin 10 mg + Sitagliptin 100 mg on the fetus, its safety is not clearly established. Therefore, if you are pregnant or planning to conceive, inform your doctor.

Breastfeeding

Small amounts of Dapagliflozin 10 mg + Sitagliptin 100 mg pass into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop it.

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage. As the drug is made into a less toxic form in the liver and kidney, consult a doctor before using it.

Avoid alcohol and smoking simultaneously, as they may affect the drug’s action and show an effect on blood glucose levels by affecting the liver and pancreas. It can sometimes increase blood sugar levels and sometimes decrease blood sugar levels.

Avoid taking Dapagliflozin 10 mg + Sitagliptin 100 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Dapagliflozin-(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol

Sitagliptin-(2S)-1-[2-[(3-hydroxyadamantan-1-yl) amino]acetyl] pyrrolidine-2-carbonitrile 

Daily dose

Take Dapagliflozin 10 mg + Sitagliptin 100 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 300 mg of dapagliflozin + sitagliptin per day, as it may cause severe overdosing effects like extreme dizziness, confusion, low blood pressure, liver damage, low blood sugar levels, swelling, muscle damage, and seizures. Immediately give the patient fruit or glucose-containing liquids and sugary foods to minimize the effects.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

1. Take Dapagliflozin 10 mg + Sitagliptin 100 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Dapagliflozin 10 mg + Sitagliptin 100 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Dapagliflozin 10 mg + Sitagliptin 100 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

What is the maximum dose of sitagliptin per day?

It is not recommended to take more than 400 mg of sitagliptin per day, as it may cause severe overdosing effects like extreme dizziness, confusion, low blood pressure, liver damage, low blood sugar levels, swelling, muscle damage, and seizures. Immediately give the patient fruit or glucose-containing liquids and sugary foods to minimize the effects. 

What are the side effects of Dapagliflozin 10 mg + Sitagliptin 100 mg?

Dapagliflozin 10 mg + Sitagliptin 100 mg is a tablet taken by people with type 2 diabetes to help keep their blood sugar levels under control. Most people tolerate it well, but some may get common side effect like feeling tired or headaches or have minor stomach issues.

What is the mechanism of action of sitagliptin?

Your body is like a classroom, and sugar is homework for your cells. Insulin helps deliver the homework, but in diabetes, some cells stop accepting it, so sugar builds up in the blood. GLP-1 and GIP are helpers that remind cells to take the sugar, but DPP-4 makes them leave too soon. Sitagliptin stops DPP-4, so the helpers stay longer and help the body use sugar better.

What are the uses of Dapagliflozin 10 mg + Sitagliptin 100 mg?

Dapagliflozin 10 mg + Sitagliptin 100 mg is an oral antidiabetic tablet used to treat type 2 diabetes by promoting the insulin production and inhibiting an insulin-killing enzyme known as dipeptidyl peptidase.

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