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Calcitriol 0.25 mcg is the active form of vitamin D3 used to treat conditions like chronic kidney disease, hypoparathyroidism, and calcium or vitamin D deficiency-related bone disorders such as rickets (soft and weak bones in children due to vitamin D deficiency) and osteomalacia (soft bones in adults caused by lack of vitamin D.
It works by helping the body absorb more calcium and phosphorus from food, reducing calcium loss through urine, and lowering parathyroid hormone (PTH) levels to maintain proper calcium balance and bone health. Because it is a very potent form of vitamin D, even a small overdose can lead to high calcium levels (hypercalcemia) in the body, causing symptoms like nausea, vomiting, weakness, excessive thirst, and kidney problems. To use it safely, it’s important to follow the prescribed dose, avoid extra calcium or vitamin D supplements unless advised, and get regular blood tests to monitor calcium and kidney function.
| Uses | 1. To treat low blood calcium (hypocalcemia) 2. To treat restore bone density 3. To treat reduce the softening of bone (osteomalacia) 4. To normalize the hyperactivity of the parathyroid hormone 5. To treat involuntary muscle spasm (muscle tetany) |
| Common Side Effects | 1. Dry mouth 2. Headache 3. Loss of appetite 4. Metallic taste in mouth 5. Upset stomach |
| Additional Information | Avoid consuming alcohol and tobacco with this medicine |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | To be taken orally |
Calcitriol 0.25 mcg is an oral medicine used to treat following indications:
Calcitriol 0.25 mcg is the active form of vitamin D3, and it helps the body absorb calcium and phosphorus from the food we eat. It works mainly in the intestines by increasing the amount of calcium that enters the bloodstream. It also helps the kidneys hold on to calcium so that less is lost in urine. In addition, calcitriol plays an important role in keeping bones healthy by maintaining the right balance of calcium, and it helps control the levels of parathyroid hormone (PTH), which can affect bone strength. Overall, it supports strong bones and proper calcium levels in the body.
Avoid taking Calcitriol 0.25 mcg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Don’t eat too many calcium-rich foods (like cheese or milk) or take calcium tablets unless your doctor says so. Too much calcium along with calcitriol can be harmful to your body.
Take Calcitriol 0.25 mcg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
The recommended dose of calcitriol is 0.25–0.5 mcg per day for adults, while for children and during pregnancy the dose should be determined by the doctor based on individual needs and medical condition.
Your skin gets vitamin D when you spend time in the sun.
Fishlike salmon, sardines, and tuna have lots of vitamin D.
Eating the yellow part of eggs gives a small amount of vitamin D.
This organ meat has some natural vitamin D.
If they grow in sunlight, they can give you some vitamin D, too.
Calcitriol 0.25 mcg is used for hypocalcemia (low calcium), osteoporosis (brittle bones), osteomalacia (soft bones), hypoparathyroidism (low parathyroid hormone), and latent tetany (muscle twitching).
Common side effects of Calcitriol 0.25 mcg include hypercalcemia (high blood calcium), loss of appetite, weight loss, nausea, vomiting, headache, drowsiness, weakness, stomach discomfort, urinary tract infection, and rash.
Adult dose for calcitriol is about 0.25mcg to 0.5mcg.


Reviewed By-
Mahak PhartyalMedical Content writer and reviewer
Bachelors in Pharmacy | 3+ Year experience
Last Updated: 06 Jul 2026
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