Amoxicillin 400 mg + Clavulanate 57 mg / 5 ml syrup is an oral antibiotic commonly prescribed (especially for children) to treat bacterial infections of the ear, throat, tonsils, sinuses, chest (bronchitis or pneumonia), urinary tract, skin, and teeth. Amoxicillin kills the germs by breaking their outer wall, while clavulanate prevents bacteria from destroying the antibiotic, making the treatment more effective.  

This syrup should be given by mouth exactly as directed by a doctor. Common side effects include nausea, vomiting, diarrhea, stomach pain, gas, and mild rash; rare serious reactions include allergy (swelling or breathing difficulty) and severe diarrhea, which need immediate medical attention.  

Amoxycillin 400 mg + Clavulanate 57mg / 5 ml is an antibiotic medicine that belongs to the class of penicillins. Amoxycillin 400 mg + Clavulanate 57mg / 5 ml is used to kill bacteria and treat symptoms of conditions like: 

1. Throat infections such as tonsillitis and pharyngitis 
2. Ear infections (otitis media) 
3. Sinus infections 
4. Chest infections like bronchitis and pneumonia 
5. Urinary tract infections (UTIs) 
6. Skin and soft-tissue infections 
7. Dental infections     

More Common  

1. Nausea 
2. Vomiting 
3. Diarrhea 
4. Stomach pain or upset 
5. Headache 
6. Mild skin rash or itching    

Less Common 

1. Severe allergic reactions (swelling, difficulty breathing, hives) 
2. Severe diarrhea (C. difficile infection) 
3. Liver problems (jaundice, dark urine) 
4. Dizziness or fainting 
5. Yeast infections        

Amoxicillin works by blocking bacterial cell wall formation while clavulanate inhibits the formation of bacterial enzymes (beta-lactamases) that destroy amoxicillin. This combination makes it effective against bacteria resistant to amoxicillin alone. 

Allergy/Hypersensitivity

If you are allergic to this medication, taking it can cause some serious side effects like breathing problems, wheezing or serious allergic reactions. Always inform your doctor if you have had any reaction to antibiotics before using this medicine. 

Kidney Problems

If you have severe kidney disease, inform your doctor before taking this medicine as this medicine may build up in your body and increase side effects. Dose adjustment may be required. 

Severe diarrhea caused by C. difficile infection

Avoid if you previously developed severe diarrhea or any gut infection caused by bad bacteria (i .e. C. difficile) after taking antibiotics, unless your doctor decides it’s necessary. 

Liver Problems

If you have liver disease, inform your doctor before taking this medicine as liver diseases will reduce the metabolism and can lead to toxicity or side effects. Always communicate with your doctor about your past disease history. 

Amoxycillin 400 mg + Clavulanate 57mg / 5 ml can be taken with or without food. Taking it with meals may help reduce stomach upset. Avoid alcohol if it worsens nausea or dizziness. Drink plenty of water to help the body absorb and eliminate the medicine properly. 

Avoid taking Amoxycillin 400 mg + Clavulanate 57mg / 5 ml with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Amoxicillin: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 

Clavulanate: (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 

Daily dose

Take Amoxycillin 400 mg + Clavulanate 57mg / 5 ml exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take Amoxycillin 400 mg + Clavulanate 57mg / 5 ml more than 500 mg per day. Overdose may cause tremors, chest pain, fast or irregular heartbeat, nervousness, dizziness, headache, muscle cramps, or high blood pressure. In case of any of these symptoms, seek immediate medical help. 

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

1. Take Amoxycillin 400 mg + Clavulanate 57mg / 5 ml exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Amoxycillin 400 mg + Clavulanate 57mg / 5 ml without your doctor’s approval, even if you feel better. 
3. If you forget to take Amoxycillin 400 mg + Clavulanate 57mg / 5 ml, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

What are the uses of Amoxycillin 400 mg + Clavulanate 57mg / 5 ml? 

Amoxycillin 400 mg + Clavulanate 57mg / 5 ml is used to treat bacterial infections such as throat infections (tonsillitis, pharyngitis), ear infections (otitis media), sinus infections, chest infections like bronchitis and pneumonia, urinary tract infections (UTIs), skin and soft-tissue infections, dental infections, and infections caused by bacteria resistant to amoxicillin alone. 

What are the side effects of Amoxycillin 400 mg + Clavulanate 57mg / 5 ml? 

Common side effects include nausea, vomiting, diarrhea, stomach pain, headache, and mild skin rash. Rare but serious side effects may include severe allergic reactions (swelling, difficulty breathing, hives), liver problems, severe diarrhea (C. difficile infection), dizziness, and yeast infections. Seek medical help if severe symptoms occur. 

What is the mechanism of action of Amoxycillin 400 mg + Clavulanate 57mg / 5 ml? 

Amoxycillin 400 mg + Clavulanate 57mg / 5 ml works by killing bacteria. Amoxicillin blocks bacterial cell wall formation, causing bacteria to break down and die, while clavulanate inhibits bacterial enzymes (beta-lactamases) that can destroy amoxicillin. This combination makes it effective against bacteria resistant to amoxicillin alone. 

Is Amoxycillin 400 mg + Clavulanate 57mg / 5 ml safe during pregnancy? 

Amoxycillin 400 mg + Clavulanate 57mg / 5 ml is generally considered safe to use during pregnancy if clearly needed. It should only be taken under a doctor’s guidance. Always inform your doctor if you are pregnant before starting this medicine. 

Who should not take Amoxycillin 400 mg + Clavulanate 57mg / 5 ml? 

Amoxycillin 400 mg + Clavulanate 57mg / 5 ml should not be taken by people who are allergic to amoxicillin, clavulanate, penicillins, or cephalosporins. It should be used with caution in those with severe kidney or liver problems, history of antibiotic-related diarrhea, or severe allergies. Always consult a doctor before taking this medicine if any of these conditions apply. 

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