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Medicine Highlights
| Uses | 1- To treat acute and chronic schizophrenia disorders 2- To treat depressive moods in patients with schizophrenia. |
| Common Side Effects | 1- Low potassium level in body 2- Feeling lightheaded 3- Bloating |
| Additional Information | Avoid taking alcohol or tobacco with this medicine. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | The medicine should be taken orally |
Amisulpride Summary
Amisulpride is a medication used to treat schizophrenia and related depression. This medication functions by regulating dopamine levels in the brain and is available in both oral tablet and injectable forms. The injectable form is primarily administered postoperatively to prevent nausea and vomiting. It is essential to take this medication precisely as prescribed, at the same time each day. Do not discontinue use abruptly without consulting your healthcare provider. If a dose is missed, it should be taken as soon as remembered, unless it is nearly time for the next scheduled dose.
Amisulpride Uses
Amisulpride 100 mg is an oral medicine belonging to the class of dopamine receptor antagonist medicines. It is used for following indications:
- Schizophrenia
- Depression because of schizophrenia
Directions for use
- Take amisulpride exactly as prescribed by your doctor, regularly at the same time each day.
- Do not stop taking amisulpride without your doctor’s approval, even if you feel better.
- If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.
Amisulpride side effects
More Common
- Weight gain
Less Common
- Bloating
- Swelling around stomach
How Amisulpride works
Our brain has a chemical called dopamine, which acts both as a neurotransmitter (transmitting signals between different nerve cells) and as a hormone. In the case of schizophrenia, there is an increased transmission of dopamine. Amisulpride works by inhibiting dopamine from binding to dopamine receptors known as D2 and D3 receptors. Hence, it helps reduce the symptoms of schizophrenia by restoring the balance of dopamine activity in the brain.
Safety Measures and Warning
📌 1- Allergy/Hypersensitivity
If you are allergic to amisulpride, inform your doctor so they can prescribe an alternative medication.
📌 2- Diabetic Patients
If you are diabetic, inform your doctor, as this medication has been observed to increase insulin levels. Your doctor may avoid prescribing it.
📌 3- Kidney Dysfunction
This medication is primarily excreted through the kidneys. If you have kidney dysfunction, inform your doctor, who may choose a different medication.
📌 4- Cardiovascular Disease
If you have a pre-existing cardiovascular condition, inform your doctor, as amisulpride may worsen your condition.
Amisulpride with Other Medicines
Avoid taking amisulpride 100 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Amisulpride with Food Product
You should avoid taking alcohol or tobacco with this medicine as it may increase or decrease the effect of amisulpride.
Storage
- The medicine should be stored at room temperature
- Keep away from sunlight and moisture
- Keep away from the reach of children
Amisulpride Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name–
4-amino-5-(ethanesulfonyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide.
Intake routine/cycle
📌 Daily Dose
Take amisulpride exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
📌 Missed Dose
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
📌 Overdose
Overdose symptoms of amisulpride include dizziness, low blood pressure, and arrhythmia. If you know someone who is taking this medication and experiences these symptoms, seek immediate medical attention and take them to the hospital.
FAQ’s
1. What is the indication for amisulpride use?
➡️ The tablet form of amisulpride is used to treat patients with schizophrenia and depression, while the injectable form is used to prevent nausea and vomiting following surgical procedures.
2. Does amisulpride cause weight gain?
➡️ No, amisulpride does not typically cause weight gain and is considered safe when used as directed by your doctor.
Reference
- Austin Health. Amisulpride guideline [Internet]. Heidelberg (Australia): Austin Health; 2022 Dec [cited 2025 Jun 2]. Available from.
- DrugBank Online. Amisulpride (DB06288) [Internet]. Ottawa (Canada): DrugBank; c2005–2025 [cited 2025 Jun 2]. Available from.
- Drugs.com [Internet]. Amisulpride; c1996–2025 [cited 2025 Jun 2]. Available from.
- Zangani C, Giordano B, Stein HC, Bonora S, D’Agostino A, Ostinelli EG. Efficacy of amisulpride for depressive symptoms in individuals with mental disorders: A systematic review and meta-analysis. Hum Psychopharmacol. 2021 Nov;36(6):e2801. doi: 10.1002/hup.2801. Epub 2021 Jun 3. Erratum in: Hum Psychopharmacol. 2022 Mar;37(2):e2831. doi: 10.1002/hup.2831. PMID: 34727399; PMCID: PMC8596405. Available from.
- Mayo Clinic. Amisulpride (intravenous route) [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; 2025 Jun 1 [cited 2025 Jun 6]. Available from.
- Chang CK, Hung GC. Amisulpride-associated acute onset of metabolic syndrome in a schizophrenia patient. Psychiatry & Clinical Neurosciences. 2013 Feb 1;67(2). Available from.
- Aurobindo Pharma – Milpharm Ltd. Amisulpride 50 mg Tablets: summary of product characteristics [Internet]. Datapharm; 2024 May 31 [cited 2025 Jun 6]. Available from.