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Medicine Highlights
| Uses | 1- To treat depression 2- To treat anxiety |
| Common Side Effects | 1- Constipation 2- Feeling dizzy 3- Dry mouth 4- Feeling lethargic 5- Pain while peeing 6- Headaches 7- Uncleared vision |
| Additional Information | Avoid taking alcohol or tobacco with this medicine. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | The medicine should be taken orally |
Dosulepin Summary
Dosulepin 25 mg is a tricyclic antidepressant used to treat depression and anxiety by increasing brain levels of noradrenaline and serotonin. It also affects various brain receptors, which enhances its effects but may cause side effects like dry mouth, dizziness, and blurred vision. Caution is needed in people with heart, liver, kidney issues, or seizures. It should not be taken with alcohol or certain medications. Overdose can be serious and needs urgent medical care.
Dosulepin Uses
Dosulepin 25 mg is an oral medicine belonging to the class of tricyclic antidepression medicines. It is used for following indications:
- Depression
- Anxiety
Dosulepin side effects
More Common
- Constipation
- Feeling dizzy
- Dry mouth
- Feeling lethargic
- Pain while peeing
- Headaches
- Uncleared vision
Less Common
- Irregular heartbeat
- Change in color of the eye to yellow
- Confusion
- Weakness
- Change in eyesight
How Dosulepin works
Dosulepin works by increasing the level of two important brain chemicals- noradrenaline and serotonin. It works by blocking the parts of the brain that usually removes them. This means more of these mood-lifting chemicals stay in the brain. A metabolite of dosulepin called northiaden does an even better job of keeping noradrenaline in the brain. Dosulepin also affects other brain systems. It blocks α2 receptors, which allows more noradrenaline to be released, and it reduces the number of β-receptors, which lowers the brain’s response to stress. It blocks serotonin receptors called 5HT1A and 5HT2A- this helps control mood and may also improve sleep. Dosulepin can cause side effects like dry mouth by blocking muscarinic receptors, and it makes people feel sleepy by blocking histamine (H1) receptors.
Directions of use
- Take dosulepin exactly as prescribed by your doctor, regularly at the same time each day.
- Do not stop taking dosulepin without your doctor’s approval, even if you feel better.
- If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.
Safety measures and warning
📌 1- Allergy/Hypersensitivity
If you are already allergic to this medicine then inform your doctor about it. He/she will prescribe you another medicine.
📌 2- Heart Problems
If you have existing heart problems then inform your doctor about it as this dosulepin can further complicate your problem.
📌 3- Liver or kidney dysfunction
Since this medicine is processed by the liver and excreted through the kidneys, inform your doctor if you have any problems with these organs, as it may increase the risk of complications.
📌 4- Seizure
If you are taking medication to treat your seizure then inform your doctor as dosulepin can increase the chances of seizure in your body.
Dosulepin Interaction with Other Medicines
Avoid taking dosulepin 25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Dosulepin Interaction with Food Product
Dosulepin does not interact with any food products, but alcohol should be avoided before and after taking the medicine, as it can increase or decrease the effect of dosulepin.
Storage
- The medicine should be stored at cool temperature
- Keep away from sunlight and moisture
- Keep away from the reach of children
Dosulepin Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
(3Z)-3-(dibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine
Intake routine/cycle
📌 Daily Dose
Take dosulepin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
📌 Missed Dose
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
📌 Overdose
You should not take more than 750 mg of dosulepin as it can lead to toxicity. Overdosing symptoms include arrhythmia, drowsiness, and vomiting. If you know someone who takes this medicine and has these symptoms, rush them to the hospital immediately.
FAQ’s
1. What is dosulepin used for?
➡️ Dosulepin is used to treat mainly anxiety and depression.
2. Dose dosulepin cause sleep?
➡️ Yes, dosulepin makes you sleepy and it is one of its common side effects.
3. Dosulepin belongs to which class of medicine?
➡️ Dosulepin belongs to tricyclic antidepressant class of medicine.
Reference
- NHS. Side effects of dosulepin. NHS [Internet]. 2022 Mar 4 [cited 2025 May 6]; Available from.
- DrugBank. Lacosamide [Internet]. Edmonton (AB): DrugBank; [cited 2025 May 6]. Available from.
- NHS. Who can and cannot take dosulepin [Internet]. London: NHS; 2022 Mar 4 [cited 2025 May 6]. Available from.
- NHS. Who can and cannot take dosulepin [Internet]. London: NHS; 2022 Mar 4 [cited 2025 May 6]. Available from.
- NHS Dorset. Safety bulletin: Dosulepin prescribing [Internet]. Dorset: NHS Dorset; 2021 [cited 2025 May 6]. Available from.
