.ae0904af.png&w=1080&q=75)
Medicine Highlights
| Uses | 1. To control seizures like generalized, tonic-clonic, and Lennox-Gastaut syndrome 2. To treat bipolar disorder. |
| Common Side Effects | 1. Blurred vision 2. Changes in vision 3. Chest pain, discomfort, or tightness 4. Clumsiness or unsteadiness 5. Decreased urine output 6. Dilated neck veins 7. Double vision 8. Irregular breathing 9. Irregular heartbeat 10. Nausea 11. Pain or discomfort in the arms, jaw, back, or neck 12. Poor coordination 13. Skin rash 14. Sweating 15. Swelling of the face, fingers, feet, or lower legs 16. Trouble breathing 17. Unusual tiredness or weakness 18. Vomiting 19. Weight gain |
| Additional Information | Lamotrigine can cause drowsiness and dizziness, so avoid driving or using machinery to avoid accidents. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children. |
| How to Take This Medicine | Swallow this medicine with water. |
Lamotrigine Summary
Lamotrigine 25 mg is an oral anticonvulsant and mood stabilizer, commonly prescribed for epilepsy and also for off-label indications like bipolar disorder. It works by blocking sodium channels and reducing glutamate release, as glutamate is responsible for seizures. Common side effects include dizziness, headache, nausea, blurred vision, vomiting, and skin rash. High-protein meals will slightly alter its action, and caution is advised with grapefruit, caffeine, star fruit, and herbal supplements like ginseng and garcinia cambogia due to potential metabolic effects that reduce the drug’s action.
Lamotrigine Uses
Lamotrigine 25 mg is an oral medicine belonging to the category of anticonvulsants and is used for the following indications:
- Seizures
- Bipolar disorder
Lamotrigine side effects
More Common
- Blurred vision
- Changes in vision
- Chest pain, discomfort, or tightness
- Clumsiness or unsteadiness
- Decreased urine output
- Dilated neck veins
- Double vision
- Irregular breathing
- Irregular heartbeat
- Nausea
- Pain or discomfort in the arms, jaw, back, or neck
- Poor coordination
- Skin rash
- Sweating
- Swelling of the face, fingers, feet, or lower legs
- Trouble breathing
- Unusual tiredness or weakness
- Vomiting
- Weight gain
Less Common
- Anxiety
- Chest pain
- Confusion
- Continuous, uncontrolled back-and-forth or rolling eye movements
- Depression
- Increase in seizures
- Infection
- Irritability
- Blistering, peeling, or loosening of the skin
- Chills
- Cough
- Dark urine
- Diarrhea
- Fever
- General feeling of discomfort or illness
- Headache
- Itching
- Joint pain
- Loss of appetite
How Lamotrigine Works
Lamotrigine works by calming the extra electrical activity in the brain that causes seizures, which is like a dam controlling the rush of water in a river. In epilepsy, the nerves send too many signals too fast, making the body shake or freeze. Lamotrigine helps slow down this signal flow, bringing balance and keeping the mind steady.
Safety Measures and Warning
📌 Past mental health issues
Lamotrigine directly acts on the brain and causes different effects like sedation, drowsiness, and suicidal thoughts. Inform the doctor about your past mental health issues before taking the medication.
📌 Pregnancy
Lamotrigine is the most used antiepileptic drug in pregnant women. But there are no studies supporting it being safer in any research. Get a recommendation from the doctor before using it.
📌 Breastfeeding
Lamotrigine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop it.
📌 Kidney and Liver Problems
There are few cases suggesting that acute kidney disease and acute liver disease patients are more prone to liver and kidney damage due to some enzymes released in these stages interacting with the drug. So, consult a doctor if you have these problems.
Lamotrigine Interaction with Food Product
Avoid alcohol and smoking simultaneously, as together with lamotrigine, this can cause some serious side effects like confusion, hallucinations, drowsiness, and sedation. So, try to avoid alcohol consumption and smoking. Go to the hospital if you face any problems.
Lamotrigine Interaction with Other Medicines
Avoid taking Lamotrigine 25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Lamotrigine Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/Chemical name
2-[2-(4-dibenzo [1,4] thiazepin-11-yl-1-piperazinyl) ethoxy] ethanol
Intake routine/cycle
📌 Daily dose
Take Lamotrigine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
📌 Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage
📌 Overdose
It is not recommended to take more than 500 mg of lamotrigine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, high blood pressure, hallucinations, confusion, and slurred speech. Immediately seek medical care in case of any overdose symptoms.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children.
Directions of use
- If you forget to take lamotrigine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
- Take lamotrigine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking lamotrigine without your doctor’s approval, even if you feel better.
FAQ’s
1. What are lamotrigine tablets used for?
➡️ Lamotrigine is a medicine that belongs to the class of anticonvulsants used to control seizures and to treat bipolar disorder.
2. What are lamotrigine indications?
➡️ Lamotrigine belongs to the category of anticonvulsants and is used to control seizures and bipolar disorder.
3. What are lamotrigine’s side effects?
➡️ Common side effects of lamotrigine include dizziness, headaches, nausea, blurred vision, vomiting, and skin rash.
4. What is a lamotrigine overdose?
➡️ It is not recommended to take more than 500 mg of Lamotrigine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, high blood pressure, hallucinations, confusion, and slurred speech. Immediately seek medical care in case of any overdose symptoms.
Reference
- Ayala A, Muñoz MF, Argüelles S. Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal. In: Reiter RJ, Bhatia C, editors. Biomarkers in Disease: Methods, Discoveries, and Applications [Internet]. Cham: Springer, 2014. Available from.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 3878, Lamotrigine [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2025 Jul 9]. Available from.
- Mayo Clinic Staff. Lamotrigine (Oral Route) Description and Brand Names [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; 2023 [cited 2025 Jul 9]. Available from.
- WebMD. Lamotrigine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing [Internet]. [cited 2025 Jul 9]. Available from.
- Drugs.com. Lamotrigine: Uses, Dosage, Side Effects, Warnings [Internet]. [cited 2025 Jul 9]. Available from.