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Medicine Highlights
| Uses | 1- To manage blood sugar level in type 2 diabetes mellitus 2- To treat cardiovascular disease 3- Reduce kidney disease |
| Common Side Effects | 1- Bladder pain 2- Bloody or cloudy urine 3- Change in the color, amount, or odor of vaginal discharge 4- Difficult, burning, or painful urination 5- Frequent urge to urinate 6- Itching, stinging, or redness of the vaginal area 7- Lower back or side pain 8- Pain during sexual intercourse |
| Additional information | Avoid taking alcohol or tobacco with this medicine. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | The medicine should be taken orally |
Empagliflozin Summary
Empagliflozin is used for type 2 diabetes and heart health, working by removing excess sugar through urine. It helps with weight loss and blood pressure control but may increase the risk of urinary infections. Avoid it during pregnancy and consult your doctor if needed. Take the medication as prescribed, refrain from alcohol consumption, and store it appropriately. If a dose is missed, take it as soon as possible unless the next scheduled dose is approaching. In case of overdose, monitor for symptoms such as shaking, sweating, and confusion, and seek immediate medical attention.
Empagliflozin Uses
Empagliflozin 25 mg is an oral medicine belonging to the class of SGLT2 (sodium-glucose co-transporter 2) inhibitor medicines. It is used for the following indications:
- Type-2 diabetes mellitus
- Cardiovascular disease
Empagliflozin Side Effects
More Common
- Bladder pain
- Bloody or cloudy urine
- Change in the color, amount, or odor of vaginal discharge
- Difficult, burning, or painful urination
- Frequent urge to urinate
- Itching, stinging, or redness of the vaginal area
- Lower back or side pain
- Pain during sexual intercourse
Less Common
- Discharge with a strong odor from the penis
- Increased volume of pale, dilute urine
- Redness, itching, swelling, or pain around the penis
- Waking to urinate at night
How Empagliflozin Works
Empagliflozin helps lower blood sugar by blocking a protein called SGLT-2 in the kidneys. This prevents the body from reabsorbing sugar, making you pass more sugar through urine. Unlike other diabetes medications, it works without relying on insulin. For people with type 2 diabetes, taking 10 mg of empagliflozin removes about 64 grams of sugar daily, while 25 mg removes around 78 grams. Besides controlling blood sugar, it also reduces extra sodium and fluid in the body, which helps lower blood pressure and may aid in weight loss-all without raising heart rate.
Safety Measures and Warning
📌 Pregnancy
If you are planning to conceive or are pregnant, inform your doctor, as this medicine is not safe to consume during the second and third trimesters.
📌 Urinary Tract Infection
This medicine can increase the risk of urinary tract infections, so if you have one, inform your doctor.
Directions for Use
- Take empagliflozin exactly as prescribed by your doctor, regularly at the same time each day.
- Do not stop taking this medication without your doctor’s approval, even if you feel better.
- If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.
Empagliflozin Interaction with Other Medicines
Avoid taking empagliflozin 25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Empagliflozin Interaction With Food Products
Empagliflozin does not interact with any food products, but alcohol should be avoided before and after taking the medicine, as it can increase or decrease the effect of empagliflozin.
Storage
- The medicine should be stored at room temperature
- Keep away from sunlight and moisture
- Keep away from the reach of children
Empagliflozin Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name-
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
Intake Routine/Cycle
📌 Daily Dose
Take empagliflozin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
📌 Missed Dose
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
📌 Overdose
If you know someone taking this medicine who experiences trembling, shaking, sweating, and confusion, take them to the hospital immediately, as they may be overdosing.
FAQ’s
1. Which empagliflozin is best?
➡️ Empagliflozin works the same regardless of the brand, but it’s essential to choose a tested version. SayaCare provides independently tested empagliflozin for added assurance.
2. What is the maximum dose of empagliflozin?
➡️ The maximum recommended dose is 25 mg per day. Taking more than this can lead to an overdose.
3. Which class of drug does empagliflozin belong to?
➡️ Empagliflozin belongs to the class of SGLT2 inhibitors, which help lower blood sugar by promoting glucose excretion through urine.
4. Is empagliflozin still under patent in India?
➡️ No, the patent for empagliflozin expired on March 11, 2025. It was developed by Boehringer Ingelheim and marketed under the brand name Jardiance.
5. Which medicine is better: empagliflozin or dapagliflozin?
➡️ In a study conducted on 350 patients, empagliflozin was found to be more effective in reducing blood sugar levels and improving cardiometabolic parameters compared to dapagliflozin.
Reference
- Jardiance Duo – Dosage Information [Internet]. MIMS Philippines; [cited 2025 Mar 29]. Available from.
- Empagliflozin – How and When to Take It [Internet]. NHS; [cited 2025 Mar 29]. Available from.
- Sizar O, Podder V, Talati R. Empagliflozin. [Updated 2023 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from.
- Empagliflozin (Oral Route) – Description [Internet]. Mayo Clinic; [cited 2025 Mar 29]. Available from.
- Ku EJ, Lee DH, Jeon HJ, Oh TK. Empagliflozin versus dapagliflozin in patients with type 2 diabetes inadequately controlled with metformin, glimepiride and dipeptidyl peptide 4 inhibitors: A 52-week prospective observational study. Diabetes Res Clin Pract. 2019 May;151:65-73. doi: 10.1016/j.diabres.2019.04.008. Epub 2019 Apr 4. PMID: 30954510. Available from.