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Medicine Highlights
| Uses | 1- To help control blood sugar in Type 2 diabetes |
| Common Side Effects | Headache |
| Additional Information | Alcohol should be avoided both before and after taking the medicine. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | The medicine should be taken orally |
Sitagliptin Summary
Sitagliptin 50 mg helps control blood sugar in type 2 diabetes by boosting insulin release and reducing sugar production. It’s generally well-tolerated, but some may experience headaches, dizziness, nausea, or, in rare cases, serious side effects like seizures. If you have kidney, heart, or pancreatic issues, consult your doctor before use. Be mindful of drug interactions, and avoid alcohol, as it can affect blood sugar levels. Managing diabetes isn’t just about medication-it’s about lifestyle too. Eating fewer carbs, staying active, and taking medicine on time can make a big difference. Regular exercise helps lower blood sugar naturally, and skipping doses or overdosing can be risky. Store Sitagliptin properly, and if you ever experience severe side effects, seek medical help immediately.
Sitagliptin Uses
Sitagliptin 50 mg is an oral medicine belonging to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors medicines. It is used to control blood sugar in type-2 diabetes.
Directions for Use
- Take sitagliptin exactly as prescribed by your doctor, regularly at the same time each day.
- Do not stop taking sitagliptin without your doctor’s approval, even if you feel better.
- If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.
Sitagliptin side effects
More Common
- Headache
Less Common
- Anxiety
- Blurred vision
- Chills
- Cold sweats
- Confusion
- Cool, pale skin
- Depression
- Dizziness
- Fast heartbeat
- Headache
- Increased hunger
- Loss of consciousness
- Nausea
- Nightmares
- Seizures
- Shakiness
- Slurred speech
- Unusual tiredness or weakness
How Sitagliptin works
Sitagliptin controls blood sugar by preventing the breakdown of two hormones, GLP-1 and GIP. These hormones increase insulin release and reduce sugar production, helping to keep blood sugar levels stable in people with Type 2 diabetes.
Safety Measures and Warning
📌 1- Allergy/Hypersensitivity
If you have trouble breathing, body swelling, or a drop in blood pressure after taking this medication, you may be allergic to it. If you have a known allergy to this medicine, inform your doctor.
📌 2- Vital Organ Disease
If you have kidney disease, heart disease or any other pancreatic disease then inform your doctor.
Sitagliptin Interaction with Other Medicines
Avoid taking Sitagliptin 50 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Sitagliptin Interaction with Food Products
Sitagliptin does not interact with any food products, but alcohol should be avoided before and after taking the medicine, as it can increase or decrease the effect of sitagliptin.
Storage
- The medicine should be stored at room temperature
- Keep away from sunlight and moisture
- Keep away from the reach of children
Sitagliptin Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Intake routine/cycle
📌 Daily Dose
Take sitagliptin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
📌 Missed Dose
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
📌 Overdose
Overdosing symptoms of sitagliptin include stomach pain, nausea, vomiting, and dizziness. If you know someone who has taken this medicine and is experiencing these symptoms, rush them to the hospital immediately.
Dietary and Lifestyle Management
Diabetes cannot be cured permanently, but with a healthy lifestyle and exercise, it can be managed easily. Diabetic patients are advised to monitor their blood sugar level before and after meals. Following are the natural ways to manage blood sugar levels:
Food
Eating healthy is important for managing diabetes. Carbohydrates have a huge impact on our blood sugar level, as they break into sugar (glucose), which is poison for diabetic patients as they already have elevated blood sugar levels. Therefore, it is essential for a diabetic patient to count the amount of carbohydrates he is taking.
Do Exercise
Exercise plays an important role in managing diabetes. When our body moves and gets active, the muscles use blood sugar for energy, resulting in a low amount of sugar in our bloodstream. Adults are advised to exercise for at least 150 minutes a week.
Medicine
Take your medicine on time, as it is designed to lower blood sugar levels.
Avoid Alcohol
Consumptions of alcohol while on therapy with metformin increase the risk of lactic acidosis, that is, lactic acid increases in the bloodstream. Lactic acid can cause symptoms like muscle pain, difficulty breathing, stomach pain, and weakness. Alcohol also decreases the level of blood sugar. It is generally recommended to avoid alcohol while on sitagliptin.
FAQ’s
1. What is the mechanism of action of Sitagliptin?
➡️ Sitagliptin controls blood sugar by preventing the breakdown of two hormones, GLP-1 and GIP. These hormones increase insulin release and reduce sugar production, helping to keep blood sugar levels stable in people with Type 2 diabetes.
2. Which Sitagliptin is better?
➡️ Sitagliptin from SayaCare is the best medicine because, after manufacturing, SayaCare sends it to a government lab for testing. Only after passing the quality test is the medicine made available for sale.
Reference
- Mayo Clinic. Sitagliptin (oral route) [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; [cited 2025 Mar 31]. Available from.
- Scott LJ. Sitagliptin: A Review in Type 2 Diabetes. Drugs. 2017 Feb;77(2):209-224. doi: 10.1007/s40265-016-0686-9. PMID: 28078647. Available from.
- NHS. Side effects of sitagliptin [Internet]. London: National Health Service (UK); [cited 2025 Mar 31]. Available from.
- DrugBank. Sitagliptin [Internet]. Edmonton (AB): DrugBank Online; [cited 2025 Mar 31]. Available from.
- WebMD. Sitagliptin oral: uses, side effects, interactions, pictures, warnings & dosing [Internet]. [cited 2025 Mar 31]. Available from.