Heart

This drug contain Amlodipine 5 mg+ Perindopril 4 mg.

Amlodipine and perindopril are two different medications that are often prescribed together to treat hypertension (high blood pressure). Let's take a closer look at each medication and how they work individually and in combination:

Amlodipine (5mg):

Amlodipine is a calcium channel blocker. It works by inhibiting the entry of calcium ions into smooth muscle cells of blood vessels and the heart. Calcium plays a critical role in muscle contraction, including the muscles in the walls of blood vessels. By blocking calcium entry, amlodipine causes relaxation and dilation of the blood vessels, which leads to reduced peripheral resistance and lower blood pressure.,,The relaxation of blood vessels results in increased blood flow and improved oxygen delivery to tissues. Amlodipine's action helps reduce the workload on the heart, making it more efficient in pumping blood throughout the body. This can lead to a decrease in blood pressure and a reduced risk of cardiovascular complications associated with hypertension.,,Perindopril (4mg):

Perindopril belongs to a class of medications known as angiotensin-converting enzyme (ACE) inhibitors. ACE inhibitors work by inhibiting the activity of the angiotensin-converting enzyme, which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows the blood vessels and raises blood pressure.,,By blocking the production of angiotensin II, perindopril causes blood vessels to dilate and relax, leading to decreased peripheral resistance and lower blood pressure. Additionally, ACE inhibitors can have other beneficial effects, such as reducing the workload on the heart and improving its pumping efficiency. They can also help protect the heart and kidneys from the damaging effects of high blood pressure over time.,,Combination Therapy (Amlodipine 5mg + Perindopril 4mg):

The combination of amlodipine and perindopril is often prescribed for patients with hypertension who require more than one medication to achieve adequate blood pressure control. Combining amlodipine and perindopril allows for the complementary actions of both drugs, resulting in a more significant reduction in blood pressure compared to using either medication alone.,,Amlodipine and perindopril work through different mechanisms to relax blood vessels and reduce blood pressure. By combining these two drugs, the overall effect is greater than using either medication alone, and it can be more effective in managing hypertension, especially for patients with moderate to severe high blood pressure.

It's important to note that medication dosages and combinations can vary depending on individual patient factors and medical history. Always follow your healthcare provider's instructions regarding the appropriate use and dosage of medications. If you have any concerns or questions about your medication, consult your doctor for personalized advice and guidance.

Amlodipine 5mg + Perindopril 4mg is a combination medication commonly used to treat hypertension (high blood pressure). It contains two active ingredients, amlodipine and perindopril, which work together to help control blood pressure and reduce the risk of cardiovascular events. Let's take a closer look at the uses of this combination:

Hypertension (High Blood Pressure): Amlodipine is a calcium channel blocker that relaxes and widens blood vessels, making it easier for the heart to pump blood. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that also dilates blood vessels and reduces the production of certain hormones that can increase blood pressure. By combining these two drugs, the medication can effectively lower blood pressure, helping to prevent complications associated with hypertension, such as heart attacks, strokes, and kidney problems.

Chronic Stable Angina: Amlodipine is sometimes used in combination with perindopril to manage chronic stable angina, a condition where the heart's blood supply is insufficient to meet its demand during physical activity or stress. The medications help to reduce the workload on the heart and improve blood flow to the heart muscles, relieving angina symptoms like chest pain or discomfort.

It's essential to follow your healthcare provider's instructions regarding the dosage and duration of treatment with Amlodipine 5mg + Perindopril 4mg. This combination may not be suitable for everyone, and individual response to medication can vary. Always consult your doctor or healthcare professional before starting or making any changes to your medication regimen. They will consider your medical history, current health status, and any other medications you are taking to ensure the appropriate and safe use of this combination.

Swallow the tablets/capsule whole, do not crush or chew.,,Follow your doctor's instructions for adjusting your dose.

Common side effects of amlodipine may include:

Swelling in the hands, ankles, or feet (edema),,Dizziness or lightheadedness,,Flushing (redness of the skin),,Headache,,Fatigue or tiredness,,Common side effects of perindopril may include:

Dizziness or lightheadedness,,Cough,,Diarrhea or stomach upset,,Skin rash,,Less common or rare side effects that may occur with either medication include:

Fainting or severe dizziness,,Irregular heartbeat,,Chest pain or palpitations,,Swelling of the face, lips, tongue, or throat (angioedema),,Difficulty breathing.

If you experience any severe side effects or allergic reactions such as difficulty breathing or swelling of the face, lips, tongue, or throat, seek immediate medical attention.

Warning: Amlodipine is a calcium channel blocker used to treat high blood pressure (hypertension) and certain heart conditions. Perindopril is an ACE (angiotensin-converting enzyme) inhibitor, also used to manage hypertension and some heart conditions. They are often prescribed together to help control blood pressure effectively.

When taking these medications, it's essential to be aware of potential side effects and interactions. Common side effects of Amlodipine can include swelling in the ankles or feet, dizziness, and flushing. Perindopril's side effects may include a dry cough, dizziness, or headache.

However, some individuals may experience more severe side effects, and there could be potential drug interactions with other medications you might be taking. For example, combining Amlodipine and Perindopril can increase the risk of low blood pressure (hypotension) or kidney problems.

Drug drug interaction: When taken together, they may have some interactions with other drugs. Some of the notable drug interactions include:,,Potassium-Sparing Diuretics: Taking potassium-sparing diuretics (e.g., spironolactone, triamterene) along with Amlodipine and Perindopril may increase the risk of hyperkalemia (high potassium levels).,,Other Antihypertensive Medications: Combining Amlodipine and Perindopril with other blood pressure-lowering drugs may lead to a further reduction in blood pressure, possibly causing hypotension (low blood pressure).,,NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): NSAIDs like ibuprofen or naproxen can reduce the effectiveness of antihypertensive medications and may cause kidney problems when taken with Amlodipine and Perindopril.,,Lithium: The combination of lithium (used for bipolar disorder) and Amlodipine/Perindopril may increase lithium levels in the blood, potentially leading to lithium toxicity.,,Grapefruit: Grapefruit and grapefruit juice can interfere with the breakdown of Amlodipine in the body, leading to increased levels of the drug and a higher risk of side effects.,,This list is not exhaustive, and there may be other interactions depending on individual health conditions and other medications taken. Always inform your healthcare provider about all the medications, supplements, and herbal products you are taking, including over-the-counter drugs, to ensure a safe and effective treatment plan.

Drug food interaction:Amlodipine and perindopril are medications used to treat high blood pressure (hypertension). While there are no specific foods that directly interact with these medications, certain dietary considerations are important to ensure their effectiveness and safety:,,Grapefruit and grapefruit juice: Grapefruit and its juice contain compounds that can interfere with the metabolism of certain medications, including amlodipine and perindopril. This interference may lead to higher levels of the medication in the bloodstream, potentially increasing the risk of side effects. Therefore, it's generally recommended to avoid grapefruit or its juice while taking these medications.,,High-potassium foods: Perindopril is an ACE inhibitor, which can increase potassium levels in the body. While eating foods rich in potassium is generally healthy, it's important to avoid excessive consumption of high-potassium foods while on ACE inhibitors. Some examples of high-potassium foods include bananas, oranges, potatoes, spinach, and beans. Always follow your doctor's advice on dietary potassium restrictions.,,Salt/sodium:Amlodipine and perindopril are used to lower blood pressure, and excessive salt intake can counteract their effects. It's essential to maintain a balanced and low-sodium diet to help control hypertension.,,Alcohol: While moderate alcohol consumption is generally considered acceptable for most people, excessive alcohol intake can affect blood pressure levels and may interfere with the effectiveness of amlodipine and perindopril. It's best to discuss alcohol consumption with your healthcare provider.

Drug disease interaction: Some potential interactions and contraindications for amlodipine and perindopril may include:,,Hypotension: The combination of these medications may cause excessive lowering of blood pressure, leading to dizziness, lightheadedness, and fainting.,,Kidney impairment: Amlodipine and perindopril can affect kidney function, so caution is needed in patients with existing kidney problems.,,Liver impairment: Both medications can affect liver function, so they should be used cautiously in patients with liver issues.,,Potassium-sparing diuretics: The combination of amlodipine and perindopril with potassium-sparing diuretics may lead to high potassium levels in the blood (hyperkalemia).,,Other blood pressure medications: Combining amlodipine and perindopril with certain other blood pressure medications may increase the risk of hypotension or other adverse effects.,,Pregnancy and breastfeeding: These medications may not be safe during pregnancy or while breastfeeding, so it's essential to consult a doctor if you are pregnant or planning to become pregnant.

Some common contraindications for amlodipine 5mg + perindopril 4mg combination include:

Hypersensitivity or Allergy: If a patient has a known hypersensitivity or allergy to amlodipine, perindopril, or any other ACE inhibitor (a class of drugs that includes perindopril), they should not take this combination.,,History of Angioedema: Amlodipine + perindopril should be avoided in patients with a history of angioedema (a severe allergic reaction that causes swelling of the face, lips, tongue, or throat) related to ACE inhibitors.,,Severe Aortic Stenosis: Amlodipine is generally avoided in patients with severe aortic stenosis, a condition where the aortic valve is narrowed, as it may worsen the obstruction of blood flow.,,Pregnancy: The use of amlodipine and perindopril is generally not recommended during pregnancy due to potential risks to the fetus. If a woman becomes pregnant while taking these medications, she should contact her healthcare provider immediately.,,Breastfeeding: Amlodipine and perindopril may pass into breast milk and may cause harm to the nursing infant. Breastfeeding mothers should consult their doctor before using this combination.,,Renal Artery Stenosis: Patients with renal artery stenosis (narrowing of the arteries supplying blood to the kidneys) should be cautious with amlodipine + perindopril, as it may further reduce kidney function.,,Hemodynamically Unstable Heart Failure: Amlodipine is generally not recommended in patients with severe heart failure who are in a hemodynamically unstable state, meaning their heart is unable to pump enough blood to meet the body's needs.,,Hepatic Impairment: Amlodipine and perindopril should be used with caution in patients with liver problems, as the medications are metabolized in the liver.

Follow the prescribed dosage: Take the medications exactly as prescribed by your doctor. Do not increase or decrease the dosage without consulting your healthcare provider.,,Take the medications at the same time each day: This helps maintain a steady level of the drugs in your system and improves their effectiveness.,,Avoid certain medications and substances: Inform your doctor about all the medications, supplements, and herbal remedies you are taking to avoid potential interactions. Some medications, like certain antibiotics or other antihypertensive drugs, may interact with amlodipine and perindopril.,,Inform your doctor about your medical history: Make sure your doctor is aware of any past or current medical conditions you have, especially kidney or liver problems, heart conditions, diabetes, or any allergies.,,Monitor blood pressure: Regularly check your blood pressure as directed by your doctor to ensure the medications are effectively controlling your hypertension.,,Report any side effects: If you experience any adverse effects or allergic reactions while taking the medications, contact your doctor immediately.,,Avoid alcohol and grapefruit juice: Alcohol and grapefruit juice may interact with these medications and could potentially increase the risk of side effects or decrease their effectiveness.,,Stay hydrated: Drink enough water throughout the day, as some medications may cause dehydration.,,Don't stop the medications abruptly: If you want to discontinue the medications or switch to a different treatment, talk to your doctor first. Suddenly stopping antihypertensive medications can lead to a rapid increase in blood pressure, which can be dangerous.,,Follow a healthy lifestyle: Along with taking your prescribed medications, adopt a healthy lifestyle, including a balanced diet, regular exercise, stress management, and avoiding smoking, to support overall cardiovascular health.

Store this medicine at room temperature, away from sunlight and moisture.

Amlodipine 5mg + Perindopril 4mg is a combination medication commonly used to treat hypertension (high blood pressure). It contains two active ingredients, amlodipine and perindopril, which work together to help control blood pressure and reduce the risk of cardiovascular events. Let's take a closer look at the uses of this combination:

Hypertension (High Blood Pressure): Amlodipine is a calcium channel blocker that relaxes and widens blood vessels, making it easier for the heart to pump blood. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that also dilates blood vessels and reduces the production of certain hormones that can increase blood pressure. By combining these two drugs, the medication can effectively lower blood pressure, helping to prevent complications associated with hypertension, such as heart attacks, strokes, and kidney problems.

Chronic Stable Angina: Amlodipine is sometimes used in combination with perindopril to manage chronic stable angina, a condition where the heart's blood supply is insufficient to meet its demand during physical activity or stress. The medications help to reduce the workload on the heart and improve blood flow to the heart muscles, relieving angina symptoms like chest pain or discomfort.

It's essential to follow your healthcare provider's instructions regarding the dosage and duration of treatment with Amlodipine 5mg + Perindopril 4mg. This combination may not be suitable for everyone, and individual response to medication can vary. Always consult your doctor or healthcare professional before starting or making any changes to your medication regimen. They will consider your medical history, current health status, and any other medications you are taking to ensure the appropriate and safe use of this combination.