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Medicine Highlights
| Uses | 1. To treat headache 2. To treat toothache 3. To treat muscle pain 4. To treat back pain 5. To treat menstrual cramps 6. To treat postoperative pain 7. To treat joint pain (like arthritis) 8. To treat fever 9. To treat inflammation |
| Common Side Effects | 1. Nausea 2. Vomiting 3. Diarrhoea 4. Flatulence 5. Constipation 6. Thrombocytopenia (low level of platelets) 7. Neutropenia/leucopenia (low white blood cells) 8. Skin rashes (urticaria) 9. Peptic ulcers 10. Gastrointestinal bleeding 11. Dyspepsia 12. Abdominal pain 13. Colitis (inflammation of the intestine) 14. Inflammatory bowel disorder |
| Additional Information | Avoid consuming alcohol and tobacco with this medicine. |
| Storage | 1. The medicine should be stored at room temperature 2. Keep away from sunlight and moisture 3. Keep away from the reach of children |
| How to Take This Medicine | The medicine should be taken orally |
Ibuprofen + Paracetamol Summary
Ibuprofen 400 mg + Paracetamol 325 mg is a combination medicine commonly used to relieve mild to moderate pain and reduce fever. It is effective in conditions like headaches, toothaches, muscle pain, back pain, joint pain, menstrual cramps, and fever. Ibuprofen helps reduce pain, swelling, and inflammation, while paracetamol lowers fever and eases pain. This medicine should be taken after food to avoid stomach upset and only in the dose prescribed by your doctor. Avoid alcohol during treatment, as it may increase the risk of liver damage or stomach irritation. Always tell your doctor if you are suffering with liver, kidney, heart problems, or a history of ulcers. Common side effects may include nausea, stomach discomfort, dizziness, or mild rash. If symptoms persist for more than 3 to 5 days, or if you notice signs like yellowing of the skin or black stools, consult your doctor immediately.
Ibuprofen + Paracetamol Uses
Ibuprofen 400 mg + Paracetamol 325 mg is an oral medicine, it is classified under analgesic and antipyretic category of medicine. This medicine is used for the following indications:
- Headache
- Toothache
- Muscle pain
- Back pain
- Menstrual cramps
- Postoperative pain
- Joint pain (like arthritis)
- Fever
- Inflammation
Directions for use
- Take Ibuprofen + paracetamol exactly as prescribed by your doctor, regularly at the same time each day.
- Do not stop taking Ibuprofen + paracetamol without your doctor’s approval, even if you feel better.
- If you forget to take the medicine, take it as soon as you remember. Unless it’s almost time for the next one, then just skip it.
Ibuprofen + Paracetamol side effects
More Common
- Nausea
- Vomiting
- Diarrhea
- Flatulence
- Constipation
- Thrombocytopenia (low level of platelets)
- Neutropenia/leucopenia (low white blood cells)
- Skin rashes (urticaria)
- Peptic ulcers
- Gastrointestinal bleeding
- Dyspepsia
- Abdominal pain
- Colitis (inflammation of the intestine)
- Inflammatory bowel disorder
Less Common
- Flatulence (gas)
- Mild abdominal cramps or discomfort
- Mild rash or itching
- Increased sensitivity to sunlight
How Ibuprofen+ Paracetamol works
Ibuprofen + Paracetamol is a combination of two medications: Ibuprofen and Paracetamol. Ibuprofen provides analgesic (pain-relieving) and anti-inflammatory effects by blocking the action of prostaglandins, the chemical messengers responsible for pain and inflammation in the body. Paracetamol, on the other hand, acts as a mild analgesic and antipyretic (fever reducer). It helps lower fever and relieve mild pain by inhibiting prostaglandin synthesis in the brain and promoting heat loss through sweating, which helps reset the body’s temperature control center in the part of the brain called hypothalamus. Together, these two drugs work synergistically to offer faster and more effective relief from mild to moderate pain and fever.
Safety Measures and Warning
📌 1. Allergy/hypersensitivity
If you have previously had an allergy to this medicine, inform your doctor.
📌 2. Stomach Issues
Use with caution if you have a history of ulcers, acidity, or gastrointestinal bleeding. Always take the medicine with food or milk to minimize stomach upset.
📌 3. Alcohol Abuse
Avoid alcohol while taking this medication, as it increases the risk of liver toxicity and gastro-intestinal bleeding.
📌 4. Kidney Disease
Ibuprofen may affect kidney function, especially in dehydrated individuals or those with kidney disease. Ensure adequate hydration during use.
📌 5. Heart Conditions
Use cautiously if you have any cardiac related issues like high blood pressure, heart failure, or other cardiovascular diseases. Long-term use of this medication may increase the risk of heart attack or stroke.
📌 6. Pregnancy and Breastfeeding
Avoid, especially during the third trimester of pregnancy unless prescribed by a doctor. Consult with your doctor if you are pregnant, planning pregnancy, or breastfeeding.
Ibuprofen + Paracetamol Interaction with Other Medicines
Avoid taking Ibuprofen + Paracetamol the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Ibuprofen + Paracetamol Interaction with Food Product
Consuming alcohol while taking Ibuprofen + Paracetamol may raise the risk of gastrointestinal bleeding and liver toxicity. Also avoid caffeinated food as it may disturb the drug levels in the body.
Storage
- The medicine should be stored at room temperature
- Keep away from sunlight and moisture
- Keep away from the reach of children
Ibuprofen + Paracetamol Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Ibuprofen– (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid
Intake routine/cycle
📌 Daily Dose
Take Ibuprofen + Paracetamol exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
📌 Missed Dose
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
📌 Overdose
Overdose of this medication includes paracetamol with not more than 4000 mg/day and ibuprofen 2,400 mg/day. if you know someone who takes this medicine and have symptoms like dizziness, confusion and vomiting then rush them to hospital immediately
FAQ’s
1. 1. What are the uses of the Ibuprofen and Paracetamol combination?
➡️ Ibuprofen 400 mg + Paracetamol 325 mg are oral medicines, and both the medicines come under Analgesic and Antipyretic. They are used for the following indications headache, toothache, muscle pain, back pain, menstrual cramps, postoperative pain, joint pain (like arthritis), fever, and inflammation
2. 2. What are ibuprofen paracetamol tablet side effects?
➡️ Most common side effects of ibuprofen paracetamol tablet are as follows: nausea, vomiting, diarrhea, flatulence, constipation, thrombocytopenia (low level of platelets), neutropenia/leucopenia (low white blood cells), skin rashes (urticaria), peptic ulcers, gastrointestinal bleeding, dyspepsia, abdominal pain, colitis (inflammation of the intestine), inflammatory bowel disorder.
3. 3. Can I take caffeine with ibuprofen paracetamol tablet?
➡️ Avoid consuming excessive caffeine (like coffee or energy drinks) while taking this medicine, as it may increase side effects like restlessness, fast heartbeat, or sleep disturbances.
4. 4. Is Ibuprofen and Paracetamol good for headache?
➡️ Both ibuprofen and paracetamol can be used for headaches, but they work differently. Ibuprofen, an NSAID (Nonsteroidal Anti-inflammatory Drug), is effective for headaches with inflammation, while paracetamol is a good option for general pain relief and fever reduction. Combining the two can be effective for more severe headaches or when one medication isn’t enough.
5. 5. What is Ibuprofen + Paracetamol brand name?
➡️ Ibuprofen + Paracetamol is sold under the brand name Ibuflam. At SayaCare, we provide the same medicine by its actual name, tested in NABL (National Accreditation Board for Testing and Calibration Laboratories) approved labs, at up to 80% lower cost than the market.
Reference
- Paracetamol versus ibuprofen – which works best and when? The Conversation [Internet]. 2023 Jun 26; Available from
- NHS. Common questions about paracetamol for adults [Internet]. nhs.uk. 2022. Available from
- Marketing 8BM. Ibuprofen for Headache & Migraines: A Worthy Cure? – Gold Coast Headache & Migraine Clinic [Internet]. Gold Coast Headache & Migraine Clinic. 2023 [cited 2025 Jul 18]. Available from
- Ibuprofen Plus Paracetamol : Uses, Side Effects, Dosage, Precautions & More [Internet]. CARE Hospitals. Available from
- PubChem. Acetaminophen [Internet]. National Library of Medicine. PubChem; 2019. Available from
- National Library of Medicine. Ibuprofen [Internet]. Nih.gov. PubChem; 2004. Available from
