category
Heart
composition
This drug contain Acetyl salicylic acid 150 mg + clopidogrel 75 mg.
workings
Acetyl salicylic acid (ASA) and clopidogrel are two medications that are often used together to prevent blood clots from forming in people who have certain conditions, such as coronary artery disease or who have had a heart attack or stroke.
Acetyl salicylic acid, also known as aspirin, works by blocking the activity of an enzyme called cyclooxygenase (COX). This enzyme is involved in the production of thromboxane, a molecule that promotes blood clotting. By inhibiting COX, ASA reduces the production of thromboxane, which in turn reduces the risk of blood clots.
Clopidogrel, on the other hand, is a platelet aggregation inhibitor. It works by blocking the activity of a molecule called ADP (adenosine diphosphate), which is involved in the activation of platelets, the small blood cells that are responsible for forming clots. By inhibiting the activation of platelets, clopidogrel reduces the risk of blood clots.
When taken together, ASA and clopidogrel have a synergistic effect, meaning that their combined action is greater than the sum of their individual effects. This combination therapy is often used after procedures such as coronary stent placement or in patients with a history of heart attack or stroke to prevent blood clots and reduce the risk of future events.
usage
Acetyl salicylic acid (ASA) and clopidogrel are both antiplatelet medications that work to prevent blood clots from forming in the body. The combination of ASA 150 mg and clopidogrel 75 mg is commonly used for a variety of medical conditions, including:
Acute coronary syndrome (ACS): This includes unstable angina (chest pain or discomfort) and myocardial infarction (heart attack). ASA and clopidogrel are often used together in the treatment of ACS to prevent further blood clots from forming in the coronary arteries.,,Stroke: ASA and clopidogrel may be used in combination to prevent blood clots that can cause strokes.,,Peripheral artery disease (PAD): This is a condition in which the arteries in the legs or arms become narrowed or blocked. ASA and clopidogrel may be used together to prevent blood clots in people with PAD.,,Coronary artery bypass grafting (CABG): ASA and clopidogrel may be used in combination after CABG surgery to prevent blood clots from forming in the grafts or arteries.
It is important to note that ASA and clopidogrel are both blood-thinning medications and can increase the risk of bleeding. Therefore, it is essential to take these medications as prescribed by a doctor and to report any signs of bleeding or bruising.
directions
Swallow the tablets/capsule whole, do not crush or chew.,,Follow your doctor's instructions for adjusting your dose.
side effects
Muscle pain and weakness,,Digestive problems such as nausea, vomiting, diarrhea, and constipation,,Headache,,Dizziness,,Rash,,Liver problems,,Increased blood sugar levels.
The side effects of acetylsalicylic acid may include:
Stomach upset, including nausea, vomiting, and stomach pain,,Heartburn,,Dizziness,,Headache,,Bleeding or bruising more easily than normal,,Allergic reactions, such as hives or swelling.
warnings
Warning: Acetyl salicylic acid (ASA) and clopidogrel are commonly used together to reduce the risk of blood clots in patients who have had a heart attack, stroke, or other cardiovascular event. However, these medications can also have side effects and potential interactions with other medications.,,One of the most significant risks associated with ASA and clopidogrel is bleeding. This is because both medications interfere with the normal clotting function of the blood. Patients who are taking these medications should be aware of the signs of bleeding, including easy bruising, prolonged bleeding from cuts, or unusual bleeding from the gums or nose. If any of these symptoms occur, patients should seek medical attention immediately.,,Other potential side effects of ASA and clopidogrel may include stomach ulcers or gastrointestinal bleeding, headache, dizziness, or rash. Patients should talk to their healthcare provider about any concerns or questions they may have about these medications.,,It is also important for patients taking ASA and clopidogrel to inform their healthcare provider of any other medications they may be taking, including over-the-counter medications and herbal supplements, as these may interact with ASA and clopidogrel and increase the risk of bleeding or other side effects.
interactions
Drug drug interaction: There are several drugs that may interact with Acetyl salicylic acid 150 mg + clopidogrel 75 mg. Some of the most significant interactions are:
Anticoagulants: Taking Acetyl salicylic acid 150 mg + clopidogrel 75 mg with other blood thinners like heparin or warfarin may increase the risk of bleeding.,,Non-steroidal anti-inflammatory drugs (NSAIDs): Taking NSAIDs with Acetyl salicylic acid 150 mg + clopidogrel 75 mg may increase the risk of bleeding and reduce the effectiveness of the medication.,,Selective serotonin reuptake inhibitors (SSRIs): Taking SSRIs with Acetyl salicylic acid 150 mg + clopidogrel 75 mg may increase the risk of bleeding.,,Proton pump inhibitors (PPIs): Taking PPIs with Acetyl salicylic acid 150 mg + clopidogrel 75 mg may reduce the effectiveness of clopidogrel.,,CYP2C19 inhibitors: Drugs that inhibit the enzyme CYP2C19, such as omeprazole, may reduce the effectiveness of clopidogrel.,,It is important to always consult with your healthcare provider or pharmacist before taking any new medications or supplements while on Acetyl salicylic acid 150 mg + clopidogrel 75 mg to avoid any potential interactions.
Drug food interaction: Acetyl salicylic acid (ASA) and clopidogrel are commonly used medications to reduce the risk of blood clots.,,When it comes to food interactions, it is recommended to avoid consuming grapefruit and grapefruit juice as it may increase the concentration of clopidogrel in the bloodstream, which can increase the risk of bleeding.,,Other foods or drinks that may interact with ASA and clopidogrel include alcohol, which can increase the risk of stomach bleeding, and green leafy vegetables, which contain vitamin K that can interfere with the effectiveness of these medications in preventing blood clots. However, it is important to maintain a balanced diet and not completely avoid these foods without consulting with a healthcare provider.,,It is always important to talk to your doctor or pharmacist about any medications you are taking, including over-the-counter and herbal remedies, to understand potential interactions and ensure safe and effective use.
Drug disease interaction: Acetylsalicylic acid (ASA) 150 mg + clopidogrel 75 mg are commonly used together as a dual antiplatelet therapy to prevent blood clot formation in patients with a history of acute coronary syndrome, ischemic stroke, or peripheral arterial disease. The combination of ASA and clopidogrel is often prescribed following procedures such as coronary artery bypass grafting, angioplasty, or stent placement.,,This combination therapy is not specific to any particular disease but is used to reduce the risk of blood clot formation in patients with a history of cardiovascular disease or those at high risk of developing it. It is important to note that ASA and clopidogrel may interact with other medications, and patients should always consult their healthcare provider before starting any new medications.
contraindications
Acetyl salicylic acid (ASA) 150 mg + clopidogrel 75 mg is a medication combination used to prevent blood clots in people with certain cardiovascular conditions, such as heart attacks, strokes, and peripheral artery disease. However, there are certain situations where this medication combination may not be appropriate.
Some of the contraindications of Acetyl salicylic acid 75 mg + clopidogrel 75 mg include:,,Allergy or hypersensitivity to either ASA or clopidogrel or any of the components of the medication.,,Active bleeding or bleeding disorders, such as hemophilia.,,Recent surgery, especially if it involved the brain, spinal cord, or eye.,,Severe liver disease, as this medication combination is metabolized by the liver.,,Severe kidney disease, as this medication combination can accumulate in the body and cause toxicity.,,Pregnancy and breastfeeding, as the safety of this medication combination has not been established in these populations.
storage
Store this medicine at room temperature, away from sunlight and moisture.
directions use
Acetyl salicylic acid (ASA) and clopidogrel are both antiplatelet medications that work to prevent blood clots from forming in the body. The combination of ASA 150 mg and clopidogrel 75 mg is commonly used for a variety of medical conditions, including:
Acute coronary syndrome (ACS): This includes unstable angina (chest pain or discomfort) and myocardial infarction (heart attack). ASA and clopidogrel are often used together in the treatment of ACS to prevent further blood clots from forming in the coronary arteries.,,Stroke: ASA and clopidogrel may be used in combination to prevent blood clots that can cause strokes.,,Peripheral artery disease (PAD): This is a condition in which the arteries in the legs or arms become narrowed or blocked. ASA and clopidogrel may be used together to prevent blood clots in people with PAD.,,Coronary artery bypass grafting (CABG): ASA and clopidogrel may be used in combination after CABG surgery to prevent blood clots from forming in the grafts or arteries.
It is important to note that ASA and clopidogrel are both blood-thinning medications and can increase the risk of bleeding. Therefore, it is essential to take these medications as prescribed by a doctor and to report any signs of bleeding or bruising.