Heart

This drug contain Sacubitril 24mg+ valsartan 26mg.

Sacubitril/valsartan is a combination medication used for the treatment of heart failure with reduced ejection fraction (HFrEF). It combines two active ingredients: sacubitril and valsartan.

Sacubitril: Sacubitril is a neprilysin inhibitor. Neprilysin is an enzyme in the body that breaks down certain hormones, including natriuretic peptides. Natriuretic peptides are natural substances that help to widen blood vessels and reduce fluid retention, which can be beneficial in heart failure. By inhibiting neprilysin, sacubitril increases the levels of natriuretic peptides, promoting vasodilation (widening of blood vessels) and diuresis (increased urine production), thereby reducing the workload on the heart and improving heart function.

Valsartan: Valsartan is an angiotensin receptor blocker (ARB). It works by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict and promotes the retention of salt and water in the body. By blocking the effects of angiotensin II, valsartan relaxes blood vessels, reduces blood pressure, and decreases the workload on the heart.

The combination of sacubitril and valsartan provides a dual mechanism of action to address heart failure. Sacubitril helps to enhance the levels of beneficial natriuretic peptides, while valsartan reduces blood pressure and improves blood flow through vasodilation. By working together, these medications can improve heart function, reduce symptoms of heart failure, and improve the overall quality of life for individuals with heart failure with reduced ejection fraction. This combination medication is known by the brand name Entresto. As with any medication, it should only be used under the guidance and prescription of a qualified healthcare professional.

Heart Failure: Sacubitril/valsartan is primarily used to treat chronic heart failure in adults. It is specifically indicated for heart failure with reduced ejection fraction, which means the heart's left ventricle doesn't pump blood effectively.,,Dual Mechanism of Action: This medication combines two active ingredients with complementary mechanisms of action to improve heart failure management. Sacubitril is a neprilysin inhibitor, and valsartan is an angiotensin receptor blocker (ARB). Together, they work to improve heart function and reduce strain on the heart.,,Neprilysin Inhibition: Sacubitril inhibits the enzyme neprilysin, which breaks down beneficial peptides involved in regulating blood vessels, sodium balance, and fluid balance. By inhibiting neprilysin, sacubitril helps to increase levels of these beneficial peptides, leading to vasodilation (widening of blood vessels) and reduced sodium and fluid retention, which can relieve the heart's workload.,,Angiotensin Receptor Blockade: Valsartan, as an ARB, blocks the action of angiotensin II, a hormone that causes blood vessels to constrict. By inhibiting angiotensin II, valsartan helps to relax and widen blood vessels, reducing blood pressure and decreasing the heart's workload.,,Clinical Benefits: Clinical trials have shown that sacubitril/valsartan reduces the risk of cardiovascular death and hospitalization for heart failure in patients with HFrEF compared to traditional heart failure treatments.,,Tolerability and Safety: Sacubitril/valsartan has been generally well-tolerated, but like all medications, it may cause side effects. Common side effects include low blood pressure, dizziness, increased potassium levels, and cough.,,Prescription and Monitoring: Sacubitril/valsartan is available only with a prescription and should be initiated and monitored under the guidance of a healthcare professional, typically a cardiologist or heart failure specialist.

It's important to note that this medication might not be suitable for everyone, and the appropriate dosage and use will depend on an individual's specific medical condition and needs. As with any medication, it's essential to follow your doctor's instructions and report any concerning side effects promptly. Never start or stop taking any medication without consulting your healthcare provider first.

Swallow the tablets/capsule whole, do not crush or chew.,,Follow your doctor's instructions for adjusting your dose.

Hypotension (low blood pressure): It can cause dizziness, lightheadedness, or fainting in some individuals, especially when starting or increasing the dose.,,Hyperkalemia (high potassium levels): This can be a concern for individuals with pre-existing kidney problems or those taking medications that can increase potassium levels.,,Cough: Some people may experience a persistent cough while taking this medication.,,Renal impairment: It may affect kidney function in some individuals.,,Angioedema: In rare cases, sacubitril/valsartan can cause swelling of the face, lips, tongue, throat, or extremities, which requires immediate medical attention.,,Dizziness and fatigue: These side effects might be experienced by some individuals.,,Digestive issues: Nausea, diarrhea, and vomiting have been reported in some cases.

Warning: The combination of these two drugs works by increasing levels of beneficial peptides in the body while blocking harmful effects of the renin-angiotensin-aldosterone system (RAAS), which helps to reduce the strain on the heart and improve heart function in heart failure patients.

Like all medications, Sacubitril/Valsartan can have potential side effects and interactions with other drugs, so it's crucial to take it as prescribed and inform your healthcare provider about any other medications or health conditions you have.

If you experience any concerning symptoms or adverse reactions while taking this medication, such as severe dizziness, difficulty breathing, swelling, or chest pain, seek immediate medical attention.

Always consult with your healthcare provider or pharmacist for specific information tailored to your health needs and potential risks associated with this medication. They will be the best source of advice and guidance for your situation.

Drug drug interaction: There are several drugs that may interact with sacubitril/valsartan and could potentially cause adverse effects or reduce the effectiveness of the medication. Some of these interactions include,,ACE Inhibitors: Taking sacubitril/valsartan with ACE inhibitors can increase the risk of angioedema, a serious allergic reaction that can cause swelling of the face, lips, tongue, throat, and can be life-threatening.,,Aliskiren: Combining sacubitril/valsartan with aliskiren (another medication used to treat high blood pressure) can increase the risk of kidney problems and high potassium levels in the blood.,,Potassium-Sparing Diuretics or Potassium Supplements: Taking sacubitril/valsartan with potassium-sparing diuretics or potassium supplements can also increase the risk of high potassium levels, which can be harmful to the heart and other organs.,,Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): NSAIDs may reduce the effectiveness of sacubitril/valsartan and may also lead to worsening kidney function, especially in people with pre-existing kidney issues.,,Lithium: The combination of sacubitril/valsartan and lithium (used to treat certain psychiatric conditions) may increase the levels of lithium in the blood, which can be harmful.,,Other Antihypertensive Medications: Using other blood pressure-lowering medications alongside sacubitril/valsartan may further reduce blood pressure, leading to possible complications.,,It is essential to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting sacubitril/valsartan. This will help them ensure there are no potentially harmful interactions and adjust your treatment plan accordingly. Always follow your doctor's advice and never stop or adjust your medication without consulting them first.

Drug food interaction: Sacubitril/valsartan is a combination medication used to treat heart failure with reduced ejection fraction. It contains two active ingredients: sacubitril and valsartan. While there are no specific foods that directly interact with sacubitril/valsartan, it's essential to consider certain dietary factors when taking this medication.,,High-potassium foods: Valsartan, one of the components in this medication, is an angiotensin II receptor blocker (ARB). ARBs can cause a slight increase in potassium levels in some individuals. Therefore, it's advisable to avoid consuming excessive amounts of high-potassium foods like bananas, oranges, tomatoes, potatoes, and leafy greens. It doesn't mean you have to avoid these foods altogether, but moderation is key, and you should discuss your diet with your healthcare provider.,,Alcohol: Sacubitril/valsartan can lower blood pressure, and alcohol consumption can potentiate this effect, leading to dizziness or lightheadedness. It's best to limit alcohol intake or avoid it altogether, especially if your doctor has advised you to restrict alcohol consumption.,,Salt (sodium): Heart failure patients often need to monitor their sodium intake to manage fluid retention. Reducing salt in your diet can help prevent fluid buildup and manage blood pressure. Sacubitril/valsartan can already have a diuretic effect, so it's important to follow your doctor's advice regarding sodium intake.,,Grapefruit and grapefruit juice: Grapefruit and grapefruit juice can interfere with the metabolism of certain medications, including valsartan. They contain compounds that inhibit an enzyme called CYP3A4, which is responsible for metabolizing valsartan. This interference can lead to increased levels of the medication in the bloodstream, potentially causing adverse effects. It's best to avoid grapefruit and grapefruit juice while taking sacubitril/valsartan.

Always follow your healthcare provider's instructions and discuss any concerns or dietary considerations with them. They can provide personalized advice based on your specific health condition and medical history. Additionally, never make any significant changes to your diet or medication regimen without consulting your healthcare professional.

Drug disease interaction: Sacubitril/valsartan is a medication used to treat heart failure with reduced ejection fraction (HFrEF). It is a combination drug that includes sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin receptor blocker (ARB).,,This combination therapy is commonly known by the brand name Entresto. It works by increasing the levels of beneficial peptides while blocking the harmful effects of angiotensin II, leading to vasodilation and reduced strain on the heart.

Sacubitril/valsartan has been shown to improve symptoms, reduce hospitalizations, and decrease mortality in patients with heart failure with reduced ejection fraction. However, like all medications, it may interact with other drugs or medical conditions, so it is essential to consult a healthcare professional before starting or changing any medication regimen. They can assess the specific health situation and provide appropriate advice and guidance.

Hypersensitivity: Patients with a known hypersensitivity or allergy to Sacubitril or Valsartan should not take this medication.,,History of Angioedema: Sacubitril/Valsartan has been associated with an increased risk of angioedema (swelling of the face, lips, tongue, or throat). Therefore, patients with a history of angioedema related to previous angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) use should avoid this medication.,,Pregnancy: Sacubitril/Valsartan can cause harm to the fetus during pregnancy, so it is contraindicated in pregnant women. Adequate contraceptive measures should be taken to prevent pregnancy while on this medication.,,Concomitant Use with ACE Inhibitors: The concurrent use of Sacubitril/Valsartan with ACE inhibitors is not recommended due to an increased risk of angioedema.,,Severe Liver Impairment: Patients with severe liver impairment should avoid Sacubitril/Valsartan, as it may exacerbate the condition.,,Severe Renal Impairment: Patients with severe renal impairment may not be suitable candidates for this medication, as it may further compromise kidney function.,,Concomitant Use with Aliskiren: The concomitant use of Sacubitril/Valsartan with Aliskiren (another medication used to treat hypertension) is not recommended in patients with diabetes.

Follow Prescribed Dosage: Take the medication exactly as prescribed by your doctor. Do not adjust the dosage or stop taking it without consulting your healthcare provider.,,Inform Your Doctor: Ensure your doctor is aware of all your medical conditions, allergies, and other medications you are taking, including over-the-counter drugs and supplements. This will help avoid potential interactions and ensure the medication is safe for you.,,Regular Check-ups: Attend all scheduled follow-up appointments with your doctor. They will monitor your progress and check for any adverse reactions or changes in your health.,,Avoid Alcohol: Limit or avoid alcohol consumption while taking this medication, as alcohol may interact with it and cause adverse effects.,,Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor before starting this medication. They will assess the risks and benefits for your specific situation.,,Kidney and Liver Function: Sacubitril/valsartan may affect kidney and liver function. Your doctor may conduct regular tests to monitor these functions.,,Orthostatic Hypotension: This medication may cause a drop in blood pressure upon standing up. To avoid dizziness or fainting, rise slowly from a sitting or lying position.,,Signs of Allergic Reaction: Seek immediate medical attention if you experience signs of an allergic reaction, such as difficulty breathing, hives, or swelling of the face, lips, tongue, or throat.,,Adhere to Diet Restrictions: Follow any diet restrictions recommended by your healthcare provider while taking this medication.,,Medication Storage: Store the medication as directed on the packaging or by your pharmacist. Keep it away from moisture, light, and out of reach of children.

Store this medicine at room temperature, away from sunlight and moisture.

Heart Failure: Sacubitril/valsartan is primarily used to treat chronic heart failure in adults. It is specifically indicated for heart failure with reduced ejection fraction, which means the heart's left ventricle doesn't pump blood effectively.,,Dual Mechanism of Action: This medication combines two active ingredients with complementary mechanisms of action to improve heart failure management. Sacubitril is a neprilysin inhibitor, and valsartan is an angiotensin receptor blocker (ARB). Together, they work to improve heart function and reduce strain on the heart.,,Neprilysin Inhibition: Sacubitril inhibits the enzyme neprilysin, which breaks down beneficial peptides involved in regulating blood vessels, sodium balance, and fluid balance. By inhibiting neprilysin, sacubitril helps to increase levels of these beneficial peptides, leading to vasodilation (widening of blood vessels) and reduced sodium and fluid retention, which can relieve the heart's workload.,,Angiotensin Receptor Blockade: Valsartan, as an ARB, blocks the action of angiotensin II, a hormone that causes blood vessels to constrict. By inhibiting angiotensin II, valsartan helps to relax and widen blood vessels, reducing blood pressure and decreasing the heart's workload.,,Clinical Benefits: Clinical trials have shown that sacubitril/valsartan reduces the risk of cardiovascular death and hospitalization for heart failure in patients with HFrEF compared to traditional heart failure treatments.,,Tolerability and Safety: Sacubitril/valsartan has been generally well-tolerated, but like all medications, it may cause side effects. Common side effects include low blood pressure, dizziness, increased potassium levels, and cough.,,Prescription and Monitoring: Sacubitril/valsartan is available only with a prescription and should be initiated and monitored under the guidance of a healthcare professional, typically a cardiologist or heart failure specialist.

It's important to note that this medication might not be suitable for everyone, and the appropriate dosage and use will depend on an individual's specific medical condition and needs. As with any medication, it's essential to follow your doctor's instructions and report any concerning side effects promptly. Never start or stop taking any medication without consulting your healthcare provider first.