Pancreatin (usually containing 25,000 units of lipase along with amylase and protease) is a digestive enzyme supplement used to support digestion in individuals due to  insufficiency of pancreatin in conditions like cystic fibrosis, chronic pancreatitis, or pancreatic surgery. It aids in breaking down fats, proteins, and carbohydrates, improving nutrient absorption. The enzymes include lipase, amylase, and protease. 

It is typically taken with meals or snacks, and the dose is adjusted based on the patient’s weight and condition severity. The maximum recommended dose is not more than 10,000 lipase units/kg/day to avoid complications.

Pancreatin 25000 mg is an oral medicine and is used to treat following indications: 

1. Cystic fibrosis (Inherited lung disease) 
2. Long-term inflammation of the pancreas (chronic pancreatitis)  
3. Cancer of the pancreas 
4. Surgery on the pancreas 
5. Surgery on the upper gastrointestinal tract (gastric bypass surgery or gastrectomy) 
6. Loose, fatty stools (steatorrhea) 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

More Common  

1. Diarrhea 
2. Abdominal pain or cramps 
3. Nausea 
4. Hives or welts 
5. Headaches 
6. Mild abdominal pain 
7. Mild nausea and vomiting 

Less Common

1. Difficulty breathing 
2. Swelling of the face, lips, or eyes 
3. Swelling or constriction of the throat or tongue 
4. Wheezing 
5. Difficulty talking 
6. Dizziness 
7. Collapse  

Pancreatin is a mixture of digestive enzymes that includes lipase, amylase, and protease. These enzymes help the body break down food into simpler forms for easier digestion and absorption. Lipase breaks down fats into fatty acids and glycerol, protease breaks proteins into smaller peptides and amino acids, and amylase breaks down starch into sugars. This supports better digestion, especially in people with enzyme deficiencies. 

Allergy or hypersensitivity

Avoid taking this medication if you have a known allergy to pancreatin. If you experience symptoms like rash, swelling, or difficulty breathing, seek immediate medical attention. 

Pregnancy and Breastfeeding

Use during pregnancy or breastfeeding should be done only if advised by your doctor. 

Medical Conditions

Inform your doctor if you have gout, kidney disease, diabetes, or intestinal blockage, as pancreatin may worsen these medical conditions. 

Long-Term Use

Prolonged use may lead to high levels of uric acid or other complications. Regular monitoring may be needed. 

Pancreatin 25000 mg works best in a slightly acidic environment. Avoid taking it with non-acidic foods or liquids like milk, plain water, bananas, rice, potatoes, oatmeal, and herbal teas as it will reduce its effectiveness. This can lead to poor digestion and reduced absorption of nutrients. Additionally, avoid caffeinated food and avoiding taking alcohol and smoking can simultaneously cause an increase or decrease in drug action; also, they may cause severe drowsiness and sedation as they act on the brain directly. 

Avoid taking Pancreatin 25000 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Each enzyme in pancreatin has its own IUPAC name, for example: 

Amylase: 1,4-α-D-glucan glucanohydrolase 

Lipase: Triacylglycerol acylhydrolase 

Protease: Varies (e.g., serine endopeptidase) 

Daily dose

Take Pancreatin 25000 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

It is not recommended to take more than 2500 lipase units/kg or 10,000 lipase units/kg/day of pancreatin per day, as it may cause severe adverse effects like overdose symptoms of pancreatin may include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. 

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children  

What are pancreatin 25000 tablet price? 

The price varies depending on the brand for about 200 to 1000. At SayaCare we provide test reports with each medicine. Also, at SayaCare we provide you with up to 80% less cost than the market. 

What are the uses of Pancreatin 25000 mg? 

Pancreatin 25,000 mg is an oral medicine used to treat conditions like cystic fibrosis (thick mucus disorder), chronic pancreatitis (long-term pancreas swelling), pancreatic cancer, pancreatic surgery, upper GI surgeries (like gastric bypass), and steatorrhea (loose, fatty stools). 

What is pancreatin 25000 brand name? 

Pancreatin 25000 brand names include creon, pancreaze, pertzye, sollpura (liprotamase), ultresa, and zenpep. At SayaCare we provide the same medicine by its actual medicine name, nothing but a generic medicine, tested in national accreditation board for testing and calibration laboratories (NABL) approved labs, at up to 80% less cost than the market. 

1. Pancreatin Oral: Uses, Side Effects, Interactions, Pictures, Warnings and Dosing – WebMD [Internet]. Webmd.com. 2025 [cited 2025 Jul 17]. Available from 
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3. Pancreatin Capsules 25000 [Internet]. indiamart.com. 2023 [cited 2025 Jul 17]. Available from 
4. Lupase 25000 Tablet 10’S [Internet]. Netmeds. 2016 [cited 2025 Jul 17]. Available from