Norfloxacin 400 mg + Tinidazole 600 mg tablet is a combination medicine used to treat infections of the stomach and intestines. It may be prescribed for infectious diarrhea, amoeba infection in the intestine (amoebiasis), Giardia infection in the intestine (giardiasis), and certain bacterial infections. 

Norfloxacin works by stopping the growth of certain bacteria, while tinidazole helps kill parasites and certain bacteria that cause infections. This medicine may help relieve symptoms such as loose stools, stomach pain, abdominal cramps, and discomfort when they are caused by an infection. 

Take this medicine only as prescribed by your doctor and complete the full course, even if you start feeling better.  

Norfloxacin 400 mg + Tinidazole 600 mg tablet is mainly used to manage:

1. Infectious diarrhea 
2. Amoeba infection in the intestine (amoebiasis)  
3. Giardia infection in the intestine (giardiasis)  
4. Bacterial infections of the stomach and intestines (gastrointestinal bacterial infections)  
5. Infections caused by both bacteria and parasites (mixed bacterial and parasitic infections)       

More Common

1. Nausea or vomiting 
2. Stomach pain or discomfort 
3. Diarrhea 
4. Headache 
5. Dizziness 
6. Loss of appetite 
7. Bitter or metallic taste 
8. Dry mouth         

Less Common 

1. Severe or persistent diarrhoea 
2. Skin rash or itching 
3. Tingling or numbness in the hands or feet 
4. Unusual weakness 
5. Confusion or changes in behavior 
6. Severe dizziness 
7. Pain, swelling, or inflammation in a tendon, especially around the ankle 
8. Fast or irregular heartbeat 
9. Seizures 
10. Severe allergic reaction with swelling of the face, lips, tongue, or throat 
11. Difficulty breathing        

This medicine contains norfloxacin and tinidazole. Norfloxacin is an antibiotic that stops certain bacteria from multiplying by interfering with an enzyme they need to survive. Tinidazole works against certain parasites and bacteria by damaging their genetic material, which prevents them from growing and surviving. Together, they help treat certain infections caused by susceptible bacteria and parasites.

Allergy or Hypersensitivity

If you are allergic to norfloxacin, tinidazole, other quinolone antibiotics, or similar medicines, it may cause a rash, swelling, or breathing difficulty. Tell your doctor about any known medicine allergies before taking it.

Tendon problems

If you have a history of tendon problems or develop pain, swelling, or stiffness in a tendon while taking this medicine, stop strenuous activity and contact your doctor, as norfloxacin may increase the risk of tendon injury.

Nerve problems

If you develop numbness, tingling, burning, or weakness in your hands or feet, tell your doctor, as norfloxacin or tinidazole may affect the nerves related problems in some people.

Seizures

If you have a history of seizures or conditions that increase the risk of seizures, tell your doctor before taking this medicine, as it may increase the risk in some people.

Kidney problems

If you have kidney disease, your doctor may need to adjust the dose of norfloxacin. Tell your doctor about any kidney problems before starting treatment.

Heart rhythm problems

If you have an abnormal heart rhythm or take medicines that can affect heart rhythm, tell your doctor, as norfloxacin may increase the risk of abnormal heartbeats in some people.

Liver problems

If you have liver disease, tell your doctor before taking this medicine, as tinidazole is processed by the liver and may require medical supervision.

Alcohol

If you drink alcohol while taking tinidazole, it may cause nausea, vomiting, flushing, headache, or fast heartbeat. Avoid alcohol during treatment and for at least 3 days after the last dose.

Severe diarrhea

If you develop severe or persistent diarrhea during or after treatment, tell your doctor, as antibiotic treatment can sometimes cause a serious intestinal infection.

Pregnancy and breastfeeding

If you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor before taking this medicine. Your doctor will decide whether it is suitable for you.

This medicine can generally be taken before or after food. Avoid taking norfloxacin with milk, yoghurt, or other dairy products because they can reduce its absorption. Avoid excessive alcohol consumption, as it may increase the risk of dizziness or low blood pressure. Follow your doctor’s advice regarding fluid and salt intake during treatment.

Avoid taking Norfloxacin 400 mg + Tinidazole 600 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Norfloxacin: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid

Tinidazole: 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole

Daily dose

Take Norfloxacin 400 mg + Tinidazole 600 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Taking more than the prescribed amount may cause severe nausea, vomiting, dizziness, confusion, or other unwanted effects. If you suspect an overdose, seek immediate medical attention.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.    

What is the main use of Norfloxacin and Tinidazole combination tablets? 

It is mainly used to treat infections of the stomach and intestines, including infectious diarrhea, amoeba infection (amoebiasis), Giardia infection (giardiasis), and certain bacterial infections.

How do I take Norfloxacin and Tinidazole combination tablets for best results? 

Take the tablet exactly as prescribed by your doctor with a glass of water. Norfloxacin is generally taken on an empty stomach, usually 1 hour before or 2 hours after food. Complete the full course even if you feel better. Do not take two doses together if you miss a dose.

What are the common side effects of Norfloxacin and Tinidazole? 

Common side effects may include nausea, vomiting, stomach discomfort, diarrhea, headache, dizziness, loss of appetite, dry mouth, and a bitter or metallic taste. Contact your doctor if side effects are severe or do not improve.

Are there any dietary restrictions when taking Norfloxacin and Tinidazole? 

Yes. Take the medicine with water and avoid milk, yoghurt, and other dairy products around the time of taking norfloxacin, as they may reduce its absorption. Avoid alcohol during treatment and for at least 3 days after the last dose because tinidazole may cause nausea, vomiting, flushing, headache, or fast heartbeat when combined with alcohol.

Where can I buy Norfloxacin and Tinidazole combination tablets online? 

You can buy Norfloxacin and Tinidazole combination tablets from SayaCare, subject to prescription requirements and availability. Always purchase medicines from a reliable source and use them only as prescribed by your doctor.

Reference  

1. PubChem. Tinidazole [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Aug 24]. Available from 
2. PubChem. Norfloxacin [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Aug 24]. Available from 
3. Helmy SA, El-Assal MI. Effect of Tinidazole on Norfloxacin Disposition. Iranian Journal of Pharmaceutical Research: IJPR [Internet]. 2017 [cited 2026 Aug 24];16(4):1574. Available from