Lidocaine 1.5% + Nifedipine 0.3% ointment is used to manage anal fissures, which are small tears or cuts in the skin around the anus. These tears can cause sharp pain, burning, discomfort, and pain while or after passing stools. 

Lidocaine is a local anesthetic that temporarily numbs the area and helps reduce pain. Nifedipine helps relax the muscles around the anus, which can reduce muscle tightness and improve blood flow to the area. Together, they may help relieve symptoms and support the healing of the tears. 

Use this ointment as directed by your doctor. Along with treatment, keeping stools soft, drinking enough water, eating fiber-rich foods, and avoiding excessive straining during bowel movements may help support healing.  

Lidocaine 1.5% + Nifedipine 0.3% ointment is mainly used to help manage:

1. Pain from a small tear or cut around the anus 
2. Pain and discomfort while passing stools 
3. Tightness or muscle spasm around the anus 
4. Symptoms associated with anal fissures  

More Common

1. Mild burning or stinging 
2. Itching 
3. Redness 
4. Skin irritation 
5. Temporary numbness 
6. Headache 
7. Dizziness             

Less Common 

1. Severe skin irritation or rash 
2. Severe dizziness or weakness 
3. Fainting 
4. Swelling of the face, lips, tongue, or throat 
5. Difficulty breathing 
6. Severe allergic reaction           

This medicine contains lidocaine and nifedipine. Lidocaine temporarily numbs the area and helps reduce pain. Nifedipine relaxes the muscles around the anus, which can reduce tightness and help improve blood flow to the area. Together, they help relieve pain and support the healing of the small cuts. 

Allergy or Hypersensitivity

If you are allergic to lidocaine, nifedipine, or similar medicines, it may cause a rash, swelling, or breathing difficulty. Tell your doctor about any known medicine allergies before using it.

Severely damaged skin

If the skin around the anus is severely damaged, infected, or bleeding heavily, tell your doctor before using this ointment.

Heart problems

If you have heart disease, low blood pressure, or problems with your heartbeat, tell your doctor before using this medicine.

Liver problems

If you have liver disease, tell your doctor, as lidocaine is processed by the liver and may require additional caution.

Pregnancy and breastfeeding

If you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor before using this ointment. Your doctor will decide whether it is suitable for you.

Persistent bleeding or pain

If you continue to have bleeding, severe pain, or difficulty passing stools, consult your doctor, as another condition may need to be checked.

Food does not directly affect this medicine because it is applied to the affected area. However, drinking enough water and eating fiber-rich foods may help keep stools soft and reduce straining while passing stools.

Avoid taking Lidocaine 1.5 % + Nifedipine 0.3 % with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Lidocaine: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

Nifedipine: dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Daily dose

Take Lidocaine 1.5 % + Nifedipine 0.3 % exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Using too much ointment may cause excessive numbness, dizziness, weakness, or low blood pressure. If you suspect that you have used too much, seek medical attention.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Clean and gently dry the affected area before applying it. 
2. Apply a small amount of the ointment as directed. 
3. Wash your hands before and after application. 
4. Do not use more frequently or in larger amounts than prescribed. 
5. If you forget an application, apply it when you remember unless it is almost time for the next application. Do not apply extra ointment to make up for the missed application.     

What are the main uses of Lidocaine and Nifedipine ointment? 

It is mainly used to relieve pain and discomfort caused by anal fissures (small cuts around the anus). It also helps relax the anal muscles and may support the healing of the fissure. 

How does the combined treatment work for anal fissures? 

An anal fissure is a small tear in the skin around the anus. Lidocaine numbs the area to reduce pain, while nifedipine relaxes the muscles around the anus, helping reduce muscle tightness and support healing. 

How should I apply Lidocaine and Nifedipine ointment for best results? 

Clean and gently dry the affected area, then apply a small amount as directed by your doctor. Wash your hands before and after application. Do not use more than recommended.

Are there any side effects of Lidocaine and Nifedipine ointment? 

Some people may experience mild burning, itching, redness, skin irritation, numbness, headache, or dizziness. If you develop severe swelling or difficulty breathing, seek medical attention. 

What is the shelf life of Lidocaine and Nifedipine ointment? 

The shelf life depends on the manufacturer and formulation. Check the expiry date printed on the ointment tube or packaging, and do not use it after the expiry date. 

Is Lidocaine and Nifedipine ointment available without a prescription in India? 

It is best to use this ointment only on a doctor’s advice, especially because nifedipine is a prescription medicine. Availability and prescription requirements may vary by product and pharmacy.

How long does Lidocaine and Nifedipine ointment take to show results? 

Lidocaine may provide pain relief within a short time, while nifedipine works gradually by relaxing the anal muscles. Improvement in an anal fissure may take several weeks, depending on its severity and healing.

Where can I buy Lidocaine and Nifedipine ointment online in India? 

You can check SayaCare for Lidocaine 1.5% + Nifedipine 0.3% ointment by searching for the medicine or uploading a valid prescription, if required. SayaCare offers quality-tested generic medicines, transparent test reports, affordable pricing, and Pan-India doorstep delivery.  

Reference  

1. Vardhani GS, Arun RS, Sandhu PS, Madan R, Prabhu MS, Purandare S, et al. Effectiveness and Safety of Lidocaine-Nifedipine Combination in Patients With Acute and Chronic Anal Fissure: A Retrospective, Multi-centric, Post-marketing Surveillance Study. Cureus [Internet]. 2026 Feb 15 [cited 2026 Aug 25];. Available from 
2. PubChem. Lidocaine [Internet]. Nih.gov. PubChem; 2019 [cited 2026 Aug 25]. Available from 
3. PubChem. Nifedipine [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Aug 25]. Available from