Ketorolac Tromethamine is a pain-relieving medicine that belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to reduce pain, inflammation, and swelling in conditions such as:

1. Post-operative pain (pain after surgery) 
2. Dental pain or toothache 
3. Muscle and joint pain 
4. Injury-related pain such as sprains and strains 
5. Kidney stone pain (renal colic) 
6. Menstrual pain (dysmenorrhea)   

More Common  

1. Nausea 
2. Vomiting 
3. Stomach pain or stomach upset 
4. Indigestion (heartburn) 
5. Diarrhea or constipation 
6. Dizziness 
7. Drowsiness 
8. Headache 
9. Gas or bloating    

Less Common 

1. Nausea 
2. Vomiting 
3. Stomach upset or stomach pain 
4. Indigestion (heartburn) 
5. Dizziness 
6. Drowsiness 
7. Headache    

Ketorolac works by blocking certain natural chemicals in the body that cause pain, swelling, and inflammation. By reducing these chemicals, the medicine helps relieve pain and makes the affected area feel less swollen and uncomfortable.

Allergy or Hypersensitivity

Avoid ketorolac if you have allergic symptoms such as breathing problems or wheezing, skin rash, swelling of the face, lips, mouth, tongue, or throat, trouble swallowing, or throat tightness, as it may lead to a serious allergic reaction.

Stomach Ulcers or Bleeding

Do not take ketorolac if you have a history of stomach ulcers or gastrointestinal bleeding because it can increase the risk of severe stomach bleeding.

Kidney problems

People with severe kidney problems should avoid ketorolac as it may worsen kidney function. Inform your doctor about your past disease history.

Heart Problems

It should be avoided in people with severe heart disease or those who recently had heart surgery, as it may increase the risk of heart-related complications.

Pregnancy (especially third trimester)

Ketorolac should not be used during late pregnancy because it may harm the unborn baby and affect the baby’s heart and circulation.

Food can affect how well Ketorolac Tromethamine is tolerated by the body. It is recommended to take this medicine with food or milk to help reduce stomach irritation and discomfort. Alcohol should be avoided while taking ketorolac because it can increase the risk of stomach ulcers and bleeding. Additionally, very spicy or acidic foods may worsen stomach irritation in some people. 

Avoid taking Ketorolac Tromethamine with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Ketorolac Tromethamine: 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 

Daily dose

Take Ketorolac Tromethamine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take Ketorolac Tromethamine more than the prescribed dose (usually not exceeding 40 mg per day for oral tablets). Taking too much may lead to overdose symptoms such as severe stomach pain, nausea, vomiting, dizziness, drowsiness, or stomach bleeding. In severe cases, it may also cause kidney problems. If any unusual or severe symptoms occur, seek immediate medical help.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children. 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

Ketorolac Tromethamine 10 mg is a non-steroidal anti-inflammatory drug (NSAID) used for the short-term treatment of moderate to severe pain, especially after surgery, dental procedures, injuries, kidney stones, or severe menstrual pain. It works by blocking cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins responsible for pain, inflammation, and swelling. Common side effects include nausea, vomiting, stomach upset, dizziness, drowsiness, and headache, while serious effects such as stomach bleeding, kidney problems, or severe allergic reactions are rare but require immediate medical attention. The medicine should be used only for a short duration and strictly according to the doctor’s prescription. 

What is the drug class of Ketorolac Tromethamine? 

Ketorolac Tromethamine belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs), which are used to reduce pain, inflammation, and swelling. 

What is the mechanism of action of Ketorolac Tromethamine? 

Ketorolac works by blocking cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins chemicals responsible for pain, inflammation, and swelling thereby helping to relieve pain and inflammation. 

What are the side effects of Ketorolac Tromethamine? 

Common side effects include nausea, vomiting, stomach pain, indigestion, dizziness, drowsiness, and headache. In rare cases, it may cause serious side effects such as stomach bleeding, kidney problems, or severe allergic reactions. If severe symptoms occur, seek medical attention immediately. 

What are the uses of Ketorolac Tromethamine tablets? 

Ketorolac Tromethamine is used for the short-term treatment of moderate to severe pain such as post-operative pain, dental pain, musculoskeletal pain, kidney stone pain (renal colic), injury-related pain, and severe menstrual pain. 

1. Mahmoodi AN, Kim PY. Ketorolac [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2022. Available from 
2. Mayo Clinic. Ketorolac (Oral Route, Injection Route) Description and Brand Names – Mayo Clinic [Internet]. www.mayoclinic.org. 2025. Available from 
3. Ketorolac Tromethamine [Internet]. Available from 
4. DrugBank. Ketorolac [Internet]. go.drugbank.com. 2024. Available from