Clobetasol 0.05% + Gentamicin 0.1% + Miconazole 2% Cream is a topical medicine used for certain skin infections associated with redness, itching, swelling, and inflammation, when prescribed by a doctor. 

Clobetasol is a corticosteroid that helps reduce redness, swelling, itching, and inflammation. Gentamicin is an antibiotic that helps fight certain bacterial infections, while Miconazole is an antifungal medicine that helps control fungal growth on the skin. 

The cream may cause mild and temporary burning, stinging, itching, dryness, or irritation at the application site.  

This cream is used to treat fungal and bacterial skin infection and relieve redness, swelling, inflammation and discomfort associated with these infections 

More Common

1. Mild burning or stinging  
2. Itching  
3. Redness  
4. Dryness  
5. Skin irritation  
6. Tingling at the application site                

Less Common 

1. Skin rash  
2. Increased skin sensitivity  
3. Swelling or worsening irritation  
4. Skin thinning with prolonged or inappropriate use  
5. Changes in skin colour  
6. Other skin reactions  
7. Signs of an allergic reaction                 

Clobetasol is a corticosteroid that reduces inflammation, helping relieve redness, swelling, and itching. Gentamicin is an antibiotic that helps fight certain bacteria, while Miconazole interferes with fungal cell growth and helps control fungal infections. 

Together, these ingredients help control certain bacterial or fungal skin infections while reducing the inflammation and discomfort associated with them. 

Allergy or Hypersensitivity

If you are allergic to clobetasol, gentamicin, miconazole, other corticosteroids, antibiotics, antifungal medicines, or any ingredient in the cream, tell your doctor before using it.

Open or damaged skin

Do not apply the cream to deep wounds, open wounds, or severely damaged skin unless your doctor has advised you to do so.

Eyes and sensitive areas

Avoid contact with the eyes, mouth, nose, and other sensitive areas. If the cream accidentally gets into your eyes, rinse thoroughly with clean water.

Prolonged use

Do not use this cream for longer than prescribed. Clobetasol is a potent corticosteroid, and prolonged or excessive use may cause skin thinning, changes in skin colour, or other steroid-related side effects.

Children

Use this medicine in children only if recommended by a doctor. Children may absorb topical corticosteroids more readily and may be more likely to develop side effects.

Antibiotic use

Gentamicin is an antibiotic and should be used only when appropriate. Unnecessary or prolonged use may increase the risk of antibiotic-related problems.

Face and skin folds

Do not apply this cream to the face, groin, or skin folds unless specifically advised by your doctor, as clobetasol may cause skin damage more easily in these areas.

Worsening infection

If the affected area becomes worse, spreads, develops pus, or does not improve, consult your doctor. Do not continue using the cream for an extended period without medical advice.

As this medicine is applied to the skin, significant food interactions are not expected when it is used as directed. 

Avoid taking Clobetasol 0.05% + Gentamicin 0.1% + Miconazole 2% Cream with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Clobetasol: (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one 

Gentamicin: 2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol 

Miconazole: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

Daily dose

Apply Clobetasol 0.05% + Gentamicin 0.1% + Miconazole 2% Cream exactly as your doctor recommends. The amount and duration of use may vary depending on your skin condition and how you respond to treatment. Do not apply more or use it for longer than prescribed without consulting your doctor. 

Missed Dose

If you forget to apply the cream, apply it when you remember. If it is almost time for your next application, skip the missed application and continue with your regular schedule. Do not apply extra cream to make up for the missed application. 

Overdose

Applying too much cream may increase the risk of skin irritation, burning, or other local side effects. If the cream is accidentally swallowed, especially in a large amount, seek medical attention promptly. 

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Clean and gently dry the affected area. 
2. Apply a thin layer of cream to the affected skin as directed by your doctor. 
3. Gently spread the cream over the affected area. 
4. Wash your hands after applying it unless your hands are the treated area. 
5. Do not apply more cream than recommended. Using extra medicine will not make the infection clear faster and may increase the risk of side effects. 
6. Do not stop or extend treatment on your own without speaking with your doctor.       

What are the uses of Clobetasol + Gentamicin + Miconazole Cream? 

This cream is used to treat certain inflamed skin conditions associated with bacterial or fungal infections. It contains clobetasol to reduce inflammation, gentamicin to fight bacteria, and miconazole to treat fungal infections.

How should I use Clobetasol + Gentamicin + Miconazole Cream? 

Apply a thin layer to the affected area as directed by your doctor. Clean and dry the skin before applying it and wash your hands before and after use unless the hands are the affected area. 

What are the side effects of Clobetasol + Gentamicin + Miconazole Cream? 

Common side effects may include burning, itching, redness, irritation, dryness, or mild swelling at the application site. These effects are usually local to the skin. If you notice severe irritation, worsening symptoms, or any unusual skin changes, consult your doctor.

Can I use this cream on my face? 

Do not use this cream on your face unless your doctor has specifically prescribed it. Clobetasol is a potent corticosteroid, and using it on the face without medical advice may cause skin-related side effects.

Can I use Clobetasol + Gentamicin + Miconazole Cream for itching? 

This cream helps relieve itching when it is caused by certain inflamed skin conditions with bacterial or fungal infections. However, do not use it for unexplained itching without medical advice. 

1. PubChem. Gentamicin [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 15]. Available from 
2. PubChem. Miconazole [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 15]. Available from 
3. PubChem. Clobetasol [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 15]. Available from 
4. Indus Pharma [Internet]. Indus Pharma. 2026 [cited 2026 Sept 15]. Available from